Invitrogen

PDE4B/PDE4C/PDE4D Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-99682

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PDE4B(Accession Q07343), corresponding to amino acid residues G36-A86.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818615

Product Specific Information

Antibody detects endogenous levels of total PDE4B/C/D.

Target Information

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4B; 3',5'-cyclic-AMP phosphodiesterase 4C; 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4B; cAMP-specific phosphodiesterase 4C; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; cyclic AMP specific phosphodiesterase PDE4D5A; DPDE1; DPDE3; DPDE4; dunce; dunce-like phosphodiesterase E4; PDE21; PDE32; PDE43; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila); phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); phosphodiesterase E1 dunce homolog; testicular tissue protein Li 136

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Gene Aliases: 9630011N22Rik; ACRDYS2; DPDE1; DPDE3; DPDE4; dunce; E130301F19Rik; HSPDE4D; PDE43; PDE4B; PDE4C; PDE4D; PDE4DN2; PDEIVB; R74983; STRK1

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UniProt ID: (Human) Q07343, (Human) Q08493, (Human) Q08499, (Mouse) Q3UEI1, (Mouse) Q01063

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Entrez Gene ID: (Human) 5142, (Human) 5143, (Human) 5144, (Mouse) 18578, (Mouse) 110385, (Mouse) 238871

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Function(s)
3',5'-cyclic-AMP phosphodiesterase activity cAMP binding gamma-tubulin binding ion channel binding metal ion binding drug binding 3',5'-cyclic-nucleotide phosphodiesterase activity protein binding enzyme binding beta-2 adrenergic receptor binding ATPase binding scaffold protein binding phosphoric diester hydrolase activity hydrolase activity
Process(es)
cAMP catabolic process signal transduction negative regulation of insulin secretion neutrophil homeostasis smooth muscle contraction neutrophil chemotaxis positive regulation of interferon-gamma production positive regulation of interleukin-2 production cellular response to drug T cell receptor signaling pathway leukocyte migration cellular response to lipopolysaccharide cellular response to epinephrine stimulus regulation of cardiac muscle cell contraction regulation of high voltage-gated calcium channel activity negative regulation of relaxation of cardiac muscle regulation of heart rate aging regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum negative regulation of peptidyl-serine phosphorylation multicellular organism growth negative regulation of heart contraction regulation of ryanodine-sensitive calcium-release channel activity regulation of cell communication by electrical coupling involved in cardiac conduction regulation of receptor activity cAMP-mediated signaling regulation of cAMP metabolic process positive regulation of interleukin-5 production establishment of endothelial barrier adrenergic receptor signaling pathway adrenergic receptor signaling pathway involved in positive regulation of heart rate
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