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Product Details
PD4D3-431AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to unique amino acid sequence on PDE4D3 variant gene.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
PDE4D3 (Phosphodiesterase 4D, cAMP-specific, isoform 3) is an enzyme encoded by the PDE4D gene, which is located on chromosome 5. PDE4D3 belongs to the PDE4 family, which plays a crucial role in hydrolyzing cyclic AMP (cAMP), thereby regulating intracellular levels of this important signaling molecule. PDE4D3 is integral in modulating cAMP signaling pathways, impacting processes such as cardiac function and inflammation. This isoform of phosphodiesterase has been found to interact within a large protein complex, including Epac1, PKA, and ERK5, which is anchored by mAKAP. Phosphorylation by ERK decreases PDE4D3 activity, leading to local cAMP accumulation and increased activation of cAMP-dependent pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; DPDE3; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE4D3; PDE4D7; Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Gene Aliases: 9630011N22Rik; Dpde3; Pde4d; RCJMB04_2o18
UniProt ID: (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Chicken) 769469, (Rat) 24627, (Mouse) 238871
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
protein binding
drug binding
SH3 domain binding
enzyme binding
protein domain specific binding
cAMP binding
ubiquitin protein ligase binding
beta-2 adrenergic receptor binding
ion channel binding
metal ion binding
ATPase binding
scaffold protein binding
phosphoric diester hydrolase activity
hydrolase activity
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
aging
memory
regulation of G-protein coupled receptor protein signaling pathway
regulation of receptor activity
regulation of protein kinase A signaling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of smooth muscle cell migration
lung development
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
cellular protein complex assembly
negative regulation of heart contraction
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
leukocyte migration
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
cellular response to lipopolysaccharide
cellular response to cAMP
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in positive regulation of heart rate
negative regulation of relaxation of cardiac muscle
signal transduction
regulation of cell communication by electrical coupling involved in cardiac conduction
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