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Product Details
PD6B-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic cyclic petide common to all PDE6 Beta variants
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGMP-phosphodiesterase beta-subunit; GMP-PDE beta; phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; phosphodiesterase 6B, cGMP-specific, rod, beta; phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant); phosphodiesterase, cGMP, rod receptor, beta polypeptide; phosphodiesterase, cyclic GMP ( rod receptor), beta polypeptide; retinal degeneration 1; rod cGMP-phosphodiesterase beta-subunit; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Gene Aliases: BOS_6935; CSNB3; CSNBAD2; Mpb; PDE6B; PDEB; r; rd; rd-1; rd1; rd10; RP40
UniProt ID: (Bovine) P23439, (Human) P35913, (Mouse) P23440
Entrez Gene ID: (Bovine) 281974, (Human) 5158, (Mouse) 18587, (Rat) 289878
signal transduction
visual perception
Wnt signaling pathway, calcium modulating pathway
phototransduction, visible light
rhodopsin mediated signaling pathway
regulation of rhodopsin mediated signaling pathway
GMP metabolic process
regulation of cytosolic calcium ion concentration
retina development in camera-type eye
detection of light stimulus
response to stimulus
biological_process
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