Product References
AAV-mediated base-editing therapy ameliorates the disease phenotypes in a mouse model of retinitis pigmentosa.
Nature communications
Wu Y,Wan X,Zhao D,Chen X,Wang Y,Tang X,Li J,Li S,Sun X,Bi C,Zhang X
Published figure using PDE6B polyclonal antibody (Product # PA1-722) in Western Blot
Tue Aug 15 00:00:00 UTC 2023
In vivo base editing rescues photoreceptors in a mouse model of retinitis pigmentosa.
Molecular therapy. Nucleic acids
Su J,She K,Song L,Jin X,Li R,Zhao Q,Xiao J,Chen D,Cheng H,Lu F,Wei Y,Yang Y
PA1-722 was used in Western Blotting to demonstrate that base editing is a potential gene therapy that could provide durable protection against RP.
Tue Mar 14 00:00:00 UTC 2023
In vivo base editing rescues photoreceptors in a mouse model of retinitis pigmentosa.
Molecular therapy. Nucleic acids
Su J,She K,Song L,Jin X,Li R,Zhao Q,Xiao J,Chen D,Cheng H,Lu F,Wei Y,Yang Y
PA1-722 was used in Western Blotting to demonstrate that base editing is a potential gene therapy that could provide durable protection against RP.
Tue Mar 14 00:00:00 UTC 2023
A New Preclinical Model of Retinitis Pigmentosa Due to Pde6g Deficiency.
Ophthalmology science
Jentzsch MC,Tsang SH,Koch SF
PA1-722 was used in Immunohistochemistry to present the first detailed analysis of RP disease progression in Pde6g-deficient mice.
Fri Dec 01 00:00:00 UTC 2023
Late-stage rescue of visually guided behavior in the context of a significantly remodeled retinitis pigmentosa mouse model.
Cellular and molecular life sciences : CMLS
Kajtna J,Tsang SH,Koch SF
PA1-722 was used in Immunohistochemistry to demonstrate that when fewer than 13% of rods remain, our genetic rescue halts photoreceptor degeneration, electroretinography functional decline and inner retinal remodeling.
Wed Feb 23 00:00:00 UTC 2022
Single-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors.
International journal of molecular sciences
Chen Y,Dong Y,Yan J,Wang L,Yu S,Jiao K,Paquet-Durand F
PA1-722 was used in Immunohistochemistry-immunofluorescence to reveal cell type-specific changes in gene expression, as well as interplay between Ca2+-induced cell death and metabolic pathways.
Wed Oct 12 00:00:00 UTC 2022
Single-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors.
International journal of molecular sciences
Chen Y,Dong Y,Yan J,Wang L,Yu S,Jiao K,Paquet-Durand F
PA1-722 was used in Immunohistochemistry-immunofluorescence to reveal cell type-specific changes in gene expression, as well as interplay between Ca2+-induced cell death and metabolic pathways.
Wed Oct 12 00:00:00 UTC 2022
Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1.
The Journal of biological chemistry
Yadav RP,Boyd K,Artemyev NO
PA1-722 was used in Western Blot to conclude neither sequestration of the prenyl modifications is required for PDE6 maturation to proceed, nor is the FKBP-lipid interaction involved in the conformational switch of the enzyme into the functional state.
Tue Mar 01 00:00:00 UTC 2022
Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1.
The Journal of biological chemistry
Yadav RP,Boyd K,Artemyev NO
PA1-722 was used in Western Blot to conclude neither sequestration of the prenyl modifications is required for PDE6 maturation to proceed, nor is the FKBP-lipid interaction involved in the conformational switch of the enzyme into the functional state.
Tue Mar 01 00:00:00 UTC 2022
Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1.
The Journal of biological chemistry
Yadav RP,Boyd K,Artemyev NO
PA1-722 was used in Western Blot to conclude neither sequestration of the prenyl modifications is required for PDE6 maturation to proceed, nor is the FKBP-lipid interaction involved in the conformational switch of the enzyme into the functional state.
Tue Mar 01 00:00:00 UTC 2022
Inhibition of Epigenetic Modifiers LSD1 and HDAC1 Blocks Rod Photoreceptor Death in Mouse Models of Retinitis Pigmentosa.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Popova EY,Imamura Kawasawa Y,Zhang SS,Barnstable CJ
PA1-722 was used in Immunohistochemistry to show that inhibition of lysine demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) in rd10 mice leads to rod photoreceptor preservation and maintenance of visual function.
Wed Aug 04 00:00:00 UTC 2021
The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.
The Journal of biological chemistry
Sundar J,Matalkah F,Jeong B,Stoilov P,Ramamurthy V
PA1-722 was used in Immunohistochemistry-immunofluorescence to investigate the importance of Musashi proteins in the development and function of photoreceptor neurons in the retina.
Tue Aug 03 00:00:00 UTC 2021
The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.
The Journal of biological chemistry
Sundar J,Matalkah F,Jeong B,Stoilov P,Ramamurthy V
PA1-722 was used in Immunohistochemistry-immunofluorescence to investigate the importance of Musashi proteins in the development and function of photoreceptor neurons in the retina.
Tue Aug 03 00:00:00 UTC 2021
The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation.
The Journal of biological chemistry
Boehm AN,Bialas J,Catone N,Sacristan-Reviriego A,van der Spuy J,Groettrup M,Aichem A
PA1-722 was used in Western Blotting to show FAT10 mediates proteasomal degradation by inhibiting retinal PDE6 activity.
Fri Oct 16 00:00:00 UTC 2020
ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dilan TL,Moye AR,Salido EM,Saravanan T,Kolandaivelu S,Goldberg AFX,Ramamurthy V
Published figure using PDE6B polyclonal antibody (Product # PA1-722) in Western Blot
Wed Feb 20 00:00:00 UTC 2019
Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America
Koch SF,Duong JK,Hsu CW,Tsai YT,Lin CS,Wahl-Schott CA,Tsang SH
PA1-722 was used in Immunohistochemistry to suggest that even low-efficiency gene therapy may achieve stable survival of rescued photoreceptors in RP patients, albeit with OS dysgenesis.
Tue May 16 00:00:00 UTC 2017
Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America
Koch SF,Duong JK,Hsu CW,Tsai YT,Lin CS,Wahl-Schott CA,Tsang SH
PA1-722 was used in Immunohistochemistry to suggest that even low-efficiency gene therapy may achieve stable survival of rescued photoreceptors in RP patients, albeit with OS dysgenesis.
Tue May 16 00:00:00 UTC 2017
Halting progressive neurodegeneration in advanced retinitis pigmentosa.
The Journal of clinical investigation
Koch SF,Tsai YT,Duong JK,Wu WH,Hsu CW,Wu WP,Bonet-Ponce L,Lin CS,Tsang SH
PA1-722 was used in western blot to assess the therapeutic time window to treat retinal degenerative disease with gene therapy
Tue Sep 01 00:00:00 UTC 2015
Halting progressive neurodegeneration in advanced retinitis pigmentosa.
The Journal of clinical investigation
Koch SF,Tsai YT,Duong JK,Wu WH,Hsu CW,Wu WP,Bonet-Ponce L,Lin CS,Tsang SH
PA1-722 was used in western blot to assess the therapeutic time window to treat retinal degenerative disease with gene therapy
Tue Sep 01 00:00:00 UTC 2015
Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179.
Nature communications
Nishiguchi KM,Carvalho LS,Rizzi M,Powell K,Holthaus SM,Azam SA,Duran Y,Ribeiro J,Luhmann UF,Bainbridge JW,Smith AJ,Ali RR
PA1-722 was used in immunohistochemistry - frozen section to investigate how the Grp179 mutation contributes to bipolar cell-mediated b-waves in mice.
Fri Jan 23 00:00:00 UTC 2015
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs.
Nature communications
Zhong X,Gutierrez C,Xue T,Hampton C,Vergara MN,Cao LH,Peters A,Park TS,Zambidis ET,Meyer JS,Gamm DM,Yau KW,Canto-Soler MV
PA1-722 was used in immunocytochemistry to characterize functional photoreceptors from human iPSCs generated from three-dimensional retinal tissue
Tue Jun 10 00:00:00 UTC 2014
Atypical retinal degeneration 3 in mice is caused by defective PDE6B pre-mRNA splicing.
Vision research
Muradov H,Boyd KK,Kerov V,Artemyev NO
PA1-722 was used in immunohistochemistry, immunoprecipitation, and western blot to study atypical retinal degeneration 3 in mice caused by defective PDE6B pre-mRNA splicing
Thu Mar 15 00:00:00 UTC 2012
Atypical retinal degeneration 3 in mice is caused by defective PDE6B pre-mRNA splicing.
Vision research
Muradov H,Boyd KK,Kerov V,Artemyev NO
PA1-722 was used in immunohistochemistry, immunoprecipitation, and western blot to study atypical retinal degeneration 3 in mice caused by defective PDE6B pre-mRNA splicing
Thu Mar 15 00:00:00 UTC 2012
Atypical retinal degeneration 3 in mice is caused by defective PDE6B pre-mRNA splicing.
Vision research
Muradov H,Boyd KK,Kerov V,Artemyev NO
PA1-722 was used in immunohistochemistry, immunoprecipitation, and western blot to study atypical retinal degeneration 3 in mice caused by defective PDE6B pre-mRNA splicing
Thu Mar 15 00:00:00 UTC 2012
Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa.
Molecular therapy : the journal of the American Society of Gene Therapy
Pang JJ,Dai X,Boye SE,Barone I,Boye SL,Mao S,Everhart D,Dinculescu A,Liu L,Umino Y,Lei B,Chang B,Barlow R,Strettoi E,Hauswirth WW
Published figure using PDE6B polyclonal antibody (Product # PA1-722) in Immunofluorescence
Tue Feb 01 00:00:00 UTC 2011
Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa.
Molecular therapy : the journal of the American Society of Gene Therapy
Pang JJ,Dai X,Boye SE,Barone I,Boye SL,Mao S,Everhart D,Dinculescu A,Liu L,Umino Y,Lei B,Chang B,Barlow R,Strettoi E,Hauswirth WW
Published figure using PDE6B polyclonal antibody (Product # PA1-722) in Immunofluorescence
Tue Feb 01 00:00:00 UTC 2011
RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments.
Proceedings of the National Academy of Sciences of the United States of America
Christiansen JR,Kolandaivelu S,Bergo MO,Ramamurthy V
PA1-722 was used in immunohistochemistry to investigate the role of RAS-converting enzyme 1 RCE1 in intracellular PDE6 transport and photoreceptor viability
Tue May 24 00:00:00 UTC 2011
Ccdc66 null mutation causes retinal degeneration and dysfunction.
Human molecular genetics
Gerding WM,Schreiber S,Schulte-Middelmann T,de Castro Marques A,Atorf J,Akkad DA,Dekomien G,Kremers J,Dermietzel R,Gal A,Rülicke T,Ibrahim S,Epplen JT,Petrasch-Parwez E
PA1-722 was used in western blot to identify the role of Ccdc66 in retinitis pigmentosa
Thu Sep 15 00:00:00 UTC 2011
Function of the asparagine 74 residue of the inhibitory γ-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo.
Cellular signalling
Tsang SH,Woodruff ML,Hsu CW,Naumann MC,Cilluffo M,Tosi J,Lin CS
PA1-722 was used in western blot to investigate the effect of N74A mutation on the function of PDE6 in vivo
Sat Oct 01 00:00:00 UTC 2011
PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.
PloS one
Sahaboglu A,Tanimoto N,Kaur J,Sancho-Pelluz J,Huber G,Fahl E,Arango-Gonzalez B,Zrenner E,Ekström P,Löwenheim H,Seeliger M,Paquet-Durand F
PA1-722 was used in immunohistochemistry to study the roles of the PARP1 during retinal degeneration
Tue Nov 23 00:00:00 UTC 2010
Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q).
Investigative ophthalmology & visual science
Davis RJ,Tosi J,Janisch KM,Kasanuki JM,Wang NK,Kong J,Tsui I,Cilluffo M,Woodruff ML,Fain GL,Lin CS,Tsang SH
PA1-722 was used in western blot to characterize the phenotype of mice with homozygous missense Pde6b(H620Q) mutations and to study a gene therapy protocol.
Sat Nov 01 00:00:00 UTC 2008
Phototransduction in a transgenic mouse model of Nougaret night blindness.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Moussaif M,Rubin WW,Kerov V,Reh R,Chen D,Lem J,Chen CK,Hurley JB,Burns ME,Artemyev NO
PA1-722 was used in western blot to investigate the mechanism for Nougaret night blindness.
Wed Jun 21 00:00:00 UTC 2006
The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure.
The Journal of biological chemistry
Guo LW,Muradov H,Hajipour AR,Sievert MK,Artemyev NO,Ruoho AE
PA1-722 was used in western blot to study the interaction between the inhibitory gamma subunit and the catalytic subunit of the rod cGMP phosphodiesterase.
Fri Jun 02 00:00:00 UTC 2006
Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation.
Molecular reproduction and development
Baxendale RW,Fraser LR
PA1-722 was used in immunocytochemistry to investigate the expression and function of different PDE isoforms in mature mouse spermatozoa
Mon Aug 01 00:00:00 UTC 2005
Transducin activation state controls its light-dependent translocation in rod photoreceptors.
The Journal of biological chemistry
Kerov V,Chen D,Moussaif M,Chen YJ,Chen CK,Artemyev NO
PA1-722 was used in western blot to investigate the role of the GTP-hydrolysis on Gtalpha for light-dependent translocation in rod photoreceptors
Fri Dec 09 00:00:00 UTC 2005
AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase.
Proceedings of the National Academy of Sciences of the United States of America
Liu X,Bulgakov OV,Wen XH,Woodruff ML,Pawlyk B,Yang J,Fain GL,Sandberg MA,Makino CL,Li T
PA1-722 was used in western blot and immunohistochemistry to study the role of Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in cGMP phosphodiesterase (PDE) biosynthesis.
Tue Sep 21 00:00:00 UTC 2004
