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Product Details
MA5-51346
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8E0M8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 142-241 of human PDGFB (NP_002599.1).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3092923
Product Specific Information
Immunogen sequence: RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVTR SPGGSQEQRA KTPQTRVTIR TVRVRRPPKG KHRKFKHTHD KTALKETLGA
Target Information
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-sis; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Platelet-derived growth factor subunit B; Proto-oncogene c-Sis
Gene Aliases: PDGF-B; Pdgfb; Sis
UniProt ID: (Mouse) P31240
Entrez Gene ID: (Mouse) 18591
receptor binding
platelet-derived growth factor receptor binding
collagen binding
growth factor activity
superoxide-generating NADPH oxidase activator activity
chemoattractant activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
platelet-derived growth factor binding
embryonic placenta development
positive regulation of endothelial cell proliferation
monocyte chemotaxis
positive regulation of glomerular filtration
protein phosphorylation
substrate-dependent cell migration
multicellular organism development
synapse assembly
heart development
positive regulation of cell proliferation
response to wounding
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell migration
neuron remodeling
peptidyl-serine phosphorylation
peptidyl-tyrosine phosphorylation
glial cell development
cell projection assembly
actin cytoskeleton organization
positive regulation of cell migration
negative regulation of cell migration
positive regulation of protein autophosphorylation
negative regulation of protein binding
activation of protein kinase activity
activation of protein kinase B activity
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
paracrine signaling
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
eye photoreceptor cell development
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of DNA replication
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of mitotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
negative regulation of vasodilation
positive regulation of mitotic cell cycle, embryonic
platelet-derived growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
regulation of peptidyl-tyrosine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of chemotaxis
positive regulation of cell division
retina development in camera-type eye
cell chemotaxis
branching involved in salivary gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
cardiac vascular smooth muscle cell differentiation
positive regulation of protein tyrosine kinase activity
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
cellular response to mycophenolic acid
positive regulation of glomerular mesangial cell proliferation
metanephric glomerular mesangial cell development
metanephric glomerular mesangial cell proliferation involved in metanephros development
reactive oxygen species metabolic process
positive regulation of calcium ion import
positive regulation of hyaluronan biosynthetic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
positive regulation of metanephric mesenchymal cell migration
Performance Guarantee
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