Invitrogen

PDGFRB Monoclonal Antibody (1A2)

View all (89) PDGFRB (CD140b) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-15529

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1A2

Immunogen

Purified recombinant fragment of human PDGFRb expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979950

Product Specific Information

MA5-15529 targets PDGFRb in indirect ELISA, WB applications and shows reactivity with Human and mouse samples.

The MA5-15529 immunogen is purified recombinant fragment of human PDGFRb expressed in E. Coli.

MA5-15529 detects PDGFRb which has a predicted molecular weight of approximately 190kDa.

Target Information

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; platelet-derived growth factor receptor, beta polypeptide

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Gene Aliases: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT

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UniProt ID: (Human) P09619, (Mouse) P05622

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Entrez Gene ID: (Human) 5159, (Mouse) 18596

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Function(s)
protein tyrosine kinase activity platelet activating factor receptor activity platelet-derived growth factor-activated receptor activity platelet-derived growth factor beta-receptor activity Ras guanyl-nucleotide exchange factor activity receptor binding platelet-derived growth factor receptor binding protein binding ATP binding protein kinase binding vascular endothelial growth factor binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity platelet-derived growth factor binding nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
in utero embryonic development kidney development tissue homeostasis glycosaminoglycan biosynthetic process protein phosphorylation nitrogen compound metabolic process chemotaxis signal transduction transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development positive regulation of cell proliferation positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration phosphorylation cell migration peptidyl-tyrosine phosphorylation hemopoiesis adrenal gland development positive regulation of cell migration positive regulation of phosphoprotein phosphatase activity regulation of actin cytoskeleton organization positive regulation of collagen biosynthetic process cell migration involved in vasculogenesis intracellular signal transduction metanephric mesenchymal cell migration platelet-derived growth factor receptor-beta signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway aorta morphogenesis cellular response to platelet-derived growth factor stimulus positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of phosphatidylinositol 3-kinase activity positive regulation of mitotic nuclear division phosphatidylinositol metabolic process protein autophosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation skeletal system morphogenesis smooth muscle tissue development regulation of peptidyl-tyrosine phosphorylation positive regulation of chemotaxis cardiac myofibril assembly cell chemotaxis cardiac vascular smooth muscle cell differentiation cell migration involved in coronary angiogenesis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade smooth muscle cell chemotaxis metanephric glomerular mesangial cell proliferation involved in metanephros development metanephric glomerular capillary formation positive regulation of calcium ion import positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process MAPK cascade G-protein coupled receptor signaling pathway response to toxic substance regulation of phosphatidylinositol 3-kinase signaling response to estradiol response to retinoic acid response to fluid shear stress wound healing response to hydrogen peroxide positive regulation of GTPase activity response to estrogen phosphatidylinositol phosphorylation inner ear development response to hyperoxia metanephric mesenchyme development metanephric comma-shaped body morphogenesis metanephric S-shaped body morphogenesis
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