Proteintech

PDHB Polyclonal Antibody

PDHB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PDHB Antibody (14744-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using (Product # 14744-1-AP) (PDHB antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

PDHB Antibody in Immunoprecipitation (IP)

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Product Details

14744-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bat, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PDHB Fusion Protein Ag6442 (1-359 aa encoded by BC000439)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAVSGLVR RPLREVSGLL KRRFHWTAPA ALQVTVRDAI NQGMDEELER DEKVFLLGEE VAQYDGAYKV SRGLWKKYGD KRIIDTPISE MGFAGIAVGA AMAGLRPICE FMTFNFSMQA IDQVINSAAK TYYMSGGLQP VPIVFRGPNG ASAGVAAQHS QCFAAWYGHC PGLKVVSPWN SEDAKGLIKS AIRDNNPVVV LENELMYGVP FEFPPEAQSK DFLIPIGKAK IERQGTHITV VSHSRPVGHC LEAAAVLSKE GVECEVINMR TIRPMDMETI EASVMKTNHL VTVEGGWPQF GVGAEICARI MEGPAFNFLD APAVRVTGAD VPMPYAKILE DNSIPQVKDI IFAIKKTLNI (1-359 aa encoded by BC000439)

Target Information

PDHB (Pyruvate dehydrogenase E1 component subunit beta, mitochondrial) is also named as PHE1B. The enzyme, which is found in mitochondria, is one of the component enzymes of the pyruvate dehydrogenase multienzyme complex (PDH). It catalyzes the first reaction of an oxidative decarboxylation sequence converting pyruvate to acetyl-CoA and CO(2). Defects in PDHB are the cause of pyruvate dehydrogenase E1-beta deficiency (PDHBD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1-Arih2 axis.

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ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.

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Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.

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Critical roles of mitochondria in brain activities of torpid Myotis ricketti bats revealed by a proteomic approach.

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Proteomics

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Bioinformatics

Protein Aliases: PDHE1-B; Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; pyruvate dehydrogenase, E1 beta polypeptide

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Gene Aliases: 2610103L06Rik; AL024199; C81408; PDHB; PDHBD; PDHE1-B; PHE1B

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UniProt ID: (Human) P11177, (Rat) P49432, (Mouse) Q9D051

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Entrez Gene ID: (Human) 5162, (Rat) 289950, (Mouse) 68263

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Function(s)

pyruvate dehydrogenase activity pyruvate dehydrogenase (acetyl-transferring) activity protein binding pyruvate dehydrogenase (NAD+) activity catalytic activity oxidoreductase activity

Process(es)

glucose metabolic process acetyl-CoA biosynthetic process from pyruvate tricarboxylic acid cycle carbohydrate metabolic process metabolic process oxidation-reduction process pyruvate metabolic process regulation of acetyl-CoA biosynthetic process from pyruvate glyoxylate metabolic process mitochondrial acetyl-CoA biosynthetic process from pyruvate

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDHB Polyclonal Antibody

PDHB Antibody (14744-1-AP) in IHC (P)

Product Details

14744-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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