Proteintech

PDHX Polyclonal Antibody

PDHX Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PDHX Antibody (10951-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 10951-1-AP (PDHX antibody) at dilution of 1:100 (under 40x lens).

PDHX Antibody in Immunoprecipitation (IP)

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Product Details

10951-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:20,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PDHX Fusion Protein Ag1389 (1-501 aa encoded by BC010389)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAASWRLGC DPRLLRYLVG FPGRRSVGLV KGALGWSVSR GANWRWFHST QWLRGDPIKI LMPSLSPTME EGNIVKWLKK EGEAVSAGDA LCEIETDKAV VTLDASDDGI LAKIVVEEGS KNIRLGSLIG LIVEEGEDWK HVEIPKDVGP PPPVSKPSEP RPSPEPQISI PVKKEHIPGT LRFRLSPAAR NILEKHSLDA SQGTATGPRG IFTKEDALKL VQLKQTGKIT ESRPTPAPTA TPTAPSPLQA TAGPSYPRPV IPPVSTPGQP NAVGTFTEIP ASNIRRVIAK RLTESKSTVP HAYATADCDL GAVLKVRQDL VKDDIKVSVN DFIIKAAAVT LKQMPDVNVS WDGEGPKQLP FIDISVAVAT VKGLLTPIIK DAAAKGIQEI ADSVKALSKK ARDGKLLPEE YQGGSFSISN LGMFGIDEFT AVINPPQACI LAVGRFRPVL KLTEDEEGNA KLQQRQLITV TMSSDSRVVD DELATRFLKS FKANLENPIR LA (1-501 aa encoded by BC010389)

Target Information

The PDHX gene encodes component X of the pyruvate dehydrogenase (PDH) complex. For a detailed description of the pyruvate dehydrogenase complex. The mammalian PDH complex differs from that in E. coli and from the other mammalian alpha-keto acid dehydrogenases by the presence of a 53-kDa protein called protein X. Component X binds to the E3 component of the PDH complex (Robinson et al., 1990 ; Aral et al., 1997 ).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Singapore Grouper Iridovirus Induces Glucose Metabolism in Infected Cells by Activation of Mammalian Target of Rapamycin Signaling.

Frontiers in microbiology

Guo X,Zheng Q,Pan Z,Huang Y,Huang X,Qin Q

Fri Nov 03 00:00:00 UTC 2023

The Mitochondrial Ca²⁺ import complex is altered in ADPKD.

Cell calcium

Yanda MK,Tomar V,Cole R,Guggino WB,Cebotaru L

Sat Jan 01 00:00:00 UTC 2022

Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma.

Cancer science

Inoue J,Kishikawa M,Tsuda H,Nakajima Y,Asakage T,Inazawa J

Thu Jul 01 00:00:00 UTC 2021

Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma.

Cancer science

Inoue J,Kishikawa M,Tsuda H,Nakajima Y,Asakage T,Inazawa J

Thu Jul 01 00:00:00 UTC 2021

Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma.

Cancer science

Inoue J,Kishikawa M,Tsuda H,Nakajima Y,Asakage T,Inazawa J

Thu Jul 01 00:00:00 UTC 2021

Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity.

International journal of biological sciences

Liang C,Hao F,Yao X,Qiu Y,Liu L,Wang S,Yu C,Song Z,Bao Y,Yi J,Huang Y,Wu Y,Zheng L,Sun Y,Wang G,Yang X,Yang S,Sun L,Li Y

Thu Apr 16 00:00:00 UTC 2020

Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.

Biomolecules

Guo X,Wu S,Li N,Lin Q,Liu L,Liang H,Niu Y,Huang Z,Fu X

Mon Sep 02 00:00:00 UTC 2019

Myocardin and pdx-1 synergistically induce hMSCs to differentiate into insulin secreting cells.

Biochemical and biophysical research communications

Li JT,Sun FX

Mon Oct 06 00:00:00 UTC 2014

Myocardin and pdx-1 synergistically induce hMSCs to differentiate into insulin secreting cells.

Biochemical and biophysical research communications

Li JT,Sun FX

Mon Oct 06 00:00:00 UTC 2014

Myocardin and pdx-1 synergistically induce hMSCs to differentiate into insulin secreting cells.

Biochemical and biophysical research communications

Li JT,Sun FX

Mon Oct 06 00:00:00 UTC 2014

Myocardin and pdx-1 synergistically induce hMSCs to differentiate into insulin secreting cells.

Biochemical and biophysical research communications

Li JT,Sun FX

Mon Oct 06 00:00:00 UTC 2014

Tendons from non-diabetic humans and rats harbor a population of insulin-producing, pancreatic beta cell-like cells.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Lehner C,Gehwolf R,Wagner A,Resch H,Hirzinger C,Augat P,Stephan D,Aigner L,Rivera FJ,Bauer HC,Tempfer H

Fri Jun 01 00:00:00 UTC 2012

Tendons from non-diabetic humans and rats harbor a population of insulin-producing, pancreatic beta cell-like cells.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Lehner C,Gehwolf R,Wagner A,Resch H,Hirzinger C,Augat P,Stephan D,Aigner L,Rivera FJ,Bauer HC,Tempfer H

Fri Jun 01 00:00:00 UTC 2012

Tendons from non-diabetic humans and rats harbor a population of insulin-producing, pancreatic beta cell-like cells.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Lehner C,Gehwolf R,Wagner A,Resch H,Hirzinger C,Augat P,Stephan D,Aigner L,Rivera FJ,Bauer HC,Tempfer H

Fri Jun 01 00:00:00 UTC 2012

Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.

PloS one

Sol EM,Wagner SA,Weinert BT,Kumar A,Kim HS,Deng CX,Choudhary C

Fri May 24 00:00:00 UTC 2013

Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.

PloS one

Sol EM,Wagner SA,Weinert BT,Kumar A,Kim HS,Deng CX,Choudhary C

Fri May 24 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: component X; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX); E3-binding protein; E3BP; GSF; IDX-1; IPF-1; IPF1; IUF-1; lipoyl-containin; Lipoyl-containing pyruvate dehydrogenase complex component X; PDX-1; proX; pyruvate dehydrogenase; pyruvate dehydrogenase complex, component X; pyruvate dehydrogenase complex, E3-binding protein subunit; pyruvate dehydrogenase complex, lipoyl-containing component X; Pyruvate dehydrogenase protein X component, mitochondrial; STF-1

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Gene Aliases: Ac1164; AI481367; DLDBP; E3BP; OPDX; PDHX; PDX1; proX

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UniProt ID: (Human) O00330, (Mouse) Q8BKZ9

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Entrez Gene ID: (Human) 8050, (Rat) 311254, (Mouse) 27402

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Function(s)

protein binding transferase activity, transferring acyl groups pyruvate dehydrogenase (NAD+) activity molecular_function

Process(es)

pyruvate metabolic process regulation of acetyl-CoA biosynthetic process from pyruvate glyoxylate metabolic process mitochondrial acetyl-CoA biosynthetic process from pyruvate biological_process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDHX Polyclonal Antibody

PDHX Antibody (10951-1-AP) in IHC (P)

Product Details

10951-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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