Proteintech

PDIA6 Polyclonal Antibody

PDIA6 Antibody in Immunocytochemistry (ICC/IF)

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PDIA6 Antibody (18233-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 18233-1-AP (PDIA6 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

PDIA6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PDIA6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

18233-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PDIA6 Fusion Protein Ag12940 (1-440 aa encoded by BC001312)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to PDIA6.

Immunogen sequence: MALLVLGLV SCTFFLAVNG LYSSSDDVIE LTPSNFNREV IQSDSLWLVE FYAPWCGHCQ RLTPEWKKAA TALKDVVKVG AVDADKHHSL GGQYGVQGFP TIKIFGSNKN RPEDYQGGRT GEAIVDAALS ALRQLVKDRL GGRSGGYSSG KQGRSDSSSK KDVIELTDDS FDKNVLDSED VWMVEFYAPW CGHCKNLEPE WAAAASEVKE QTKGKVKLAA VDATVNQVLA SRYGIRGFPT IKIFQKGESP VDYDGGRTRS DIVSRALDLF SDNAPPPELL EIINEDIAKR TCEEHQLCVV AVLPHILDTG AAGRNSYLEV LLKLADKYKK KMWGWLWTEA GAQSELETAL GIGGFGYPAM AAINARKMKF ALLKGSFSEQ GINEFLRELS FGRGSTAPVG GGAFPTIVER EPWDGRDGEL PVEDDIDLSD VELDDLGKDE L (1-440 aa encoded by BC001312)

Target Information

P5 is a novel protein that was originally identified in humans. Functionally, P5 has been shown to have peptide binding ability and chaperone activity specific to certain proteins. P5 shares several structural similarities to PDI, an important protein of the ER. The deduced amino acid sequence of P5 shows that it contains the ER retention signal KDEL. P5 also contains two CXXC-like motifs, a motif responsible for oxidoreductase activity. These two CXXC motifs are found on the N- and C-terminus of the protein, one at each end. Studies suggest that the N-terminal CXXC motif is more important than the second for isomerase activity. Contrary to most of the PDI-like proteins, P5 is not stress-inducible.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells.

Journal for immunotherapy of cancer

Morimoto Y,Yamashita N,Daimon T,Hirose H,Yamano S,Haratake N,Ishikawa S,Bhattacharya A,Fushimi A,Ahmad R,Takahashi H,Dashevsky O,Mitsiades C,Kufe D

Wed Feb 01 00:00:00 UTC 2023

Venezuelan equine encephalitis virus E1 protein interacts with PDIA6 and PDI inhibition reduces alphavirus production.

Antiviral research

Panny L,Akrhymuk I,Bracci N,Woodson C,Flor R,Elliott I,Zhou W,Narayanan A,Campbell C,Kehn-Hall K

Sat Apr 01 00:00:00 UTC 2023

Venezuelan equine encephalitis virus E1 protein interacts with PDIA6 and PDI inhibition reduces alphavirus production.

Antiviral research

Panny L,Akrhymuk I,Bracci N,Woodson C,Flor R,Elliott I,Zhou W,Narayanan A,Campbell C,Kehn-Hall K

Sat Apr 01 00:00:00 UTC 2023

Venezuelan equine encephalitis virus E1 protein interacts with PDIA6 and PDI inhibition reduces alphavirus production.

Antiviral research

Panny L,Akrhymuk I,Bracci N,Woodson C,Flor R,Elliott I,Zhou W,Narayanan A,Campbell C,Kehn-Hall K

Sat Apr 01 00:00:00 UTC 2023

Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.

Cell research

Zhang S,Huang W,Ren L,Ju X,Gong M,Rao J,Sun L,Li P,Ding Q,Wang J,Zhang QC

Sat Jan 01 00:00:00 UTC 2022

A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines.

The Journal of biological chemistry

Mideksa YG,Aschenbrenner I,Fux A,Kaylani D,Weiß CAM,Nguyen TA,Bach NC,Lang K,Sieber SA,Feige MJ

Thu Dec 01 00:00:00 UTC 2022

COG4 mutation in Saul-Wilson syndrome selectively affects secretion of proteins involved in chondrogenesis in chondrocyte-like cells.

Frontiers in cell and developmental biology

Xia ZJ,Mahajan S,Paul Daniel EJ,Ng BG,Saraswat M,Campos AR,Murad R,He M,Freeze HH

Wed Jan 04 00:00:00 UTC 2023

Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis.

Nucleic acids research

Mestre-Farràs N,Guerrero S,Bley N,Rivero E,Coll O,Borràs E,Sabidó E,Indacochea A,Casillas-Serra C,Järvelin AI,Oliva B,Castello A,Hüttelmaier S,Gebauer F

Fri Aug 12 00:00:00 UTC 2022

Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".

Journal of ethnopharmacology

Han C,Jiang YH,Li W,Liu Y

Tue Apr 06 00:00:00 UTC 2021

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.

Molecular metabolism

Chhabra NF,Amend AL,Bastidas-Ponce A,Sabrautzki S,Tarquis-Medina M,Sachs S,Rubey M,Lorenz-Depiereux B,Feuchtinger A,Bakhti M,Lickert H,Przemeck GKH,Hrabě de Angelis M

Wed Dec 01 00:00:00 UTC 2021

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development.

The Journal of experimental medicine

Choi JH,Zhong X,Zhang Z,Su L,McAlpine W,Misawa T,Liao TC,Zhan X,Russell J,Ludwig S,Li X,Tang M,Anderton P,Moresco EMY,Beutler B

Mon Apr 06 00:00:00 UTC 2020

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer cell

Carugo A,Minelli R,Sapio L,Soeung M,Carbone F,Robinson FS,Tepper J,Chen Z,Lovisa S,Svelto M,Amin S,Srinivasan S,Del Poggetto E,Loponte S,Puca F,Dey P,Malouf GG,Su X,Li L,Lopez-Terrada D,Rakheja D,Lazar AJ,Netto GJ,Rao P,Sgambato A,Maitra A,Tripathi DN,Walker CL,Karam JA,Heffernan TP,Viale A,Roberts CWM,Msaouel P,Tannir NM,Draetta GF,Genovese G

Mon Feb 11 00:00:00 UTC 2019

PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.

eLife

Jang I,Pottekat A,Poothong J,Yong J,Lagunas-Acosta J,Charbono A,Chen Z,Scheuner DL,Liu M,Itkin-Ansari P,Arvan P,Kaufman RJ

Tue Jun 11 00:00:00 UTC 2019

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 UTC 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 UTC 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 UTC 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 UTC 2017

Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.

PloS one

Sun B,Bai Y,Zhang L,Gong L,Qi X,Li H,Wang F,Chi X,Jiang Y,Shao S

Sun Jul 14 00:00:00 UTC 2024

Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.

PloS one

Sun B,Bai Y,Zhang L,Gong L,Qi X,Li H,Wang F,Chi X,Jiang Y,Shao S

Sun Jul 14 00:00:00 UTC 2024

PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway.

Oncotarget

Gao H,Sun B,Fu H,Chi X,Wang F,Qi X,Hu J,Shao S

Tue Aug 16 00:00:00 UTC 2016

PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway.

Oncotarget

Gao H,Sun B,Fu H,Chi X,Wang F,Qi X,Hu J,Shao S

Tue Aug 16 00:00:00 UTC 2016

PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway.

Oncotarget

Gao H,Sun B,Fu H,Chi X,Wang F,Qi X,Hu J,Shao S

Tue Aug 16 00:00:00 UTC 2016

PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway.

Oncotarget

Gao H,Sun B,Fu H,Chi X,Wang F,Qi X,Hu J,Shao S

Tue Aug 16 00:00:00 UTC 2016

The alteration of protein profile induced by cigarette smoking via oxidative stress in mice epididymis.

The international journal of biochemistry & cell biology

Zhu Z,Xu W,Dai J,Chen X,Zhao X,Fang P,Yang F,Tang M,Wang Z,Wang L,Ma D,Qaio Z

Fri Mar 01 00:00:00 UTC 2013

The alteration of protein profile induced by cigarette smoking via oxidative stress in mice epididymis.

The international journal of biochemistry & cell biology

Zhu Z,Xu W,Dai J,Chen X,Zhao X,Fang P,Yang F,Tang M,Wang Z,Wang L,Ma D,Qaio Z

Fri Mar 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: CaBP1; Calcium-binding protein 1; Endoplasmic reticulum protein 5; ER protein 5; protein disulfide isomerase A6; protein disulfide isomerase associated 6; protein disulfide isomerase family A, member 6; Protein disulfide isomerase P5; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; Protein disulfide-isomerase A6; thioredoxin domain containing 7; thioredoxin domain containing 7 (protein disulfide isomerase); Thioredoxin domain-containing protein 7

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Gene Aliases: 1700015E05Rik; AL023058; C77895; CaBP1; CaBP5; ERP5; P5; PDIA6; TXNDC7

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UniProt ID: (Human) Q15084, (Mouse) Q922R8, (Rat) Q63081

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Entrez Gene ID: (Human) 10130, (Mouse) 71853, (Rat) 286906

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Function(s)

protein disulfide isomerase activity protein binding isomerase activity calcium ion binding

Process(es)

protein folding response to endoplasmic reticulum stress IRE1-mediated unfolded protein response apoptotic cell clearance cell redox homeostasis platelet activation platelet aggregation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDIA6 Polyclonal Antibody

PDIA6 Antibody (18233-1-AP) in ICC/IF

Product Details

18233-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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