Proteintech

PDIR Polyclonal Antibody

PDIR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PDIR Antibody (15545-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta using 15545-1-AP (PDIR antibody) at dilution of 1:100 (under 40x lens).

PDIR Antibody in Immunoprecipitation (IP)

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Product Details

15545-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PDIR Fusion Protein Ag7901 (1-262 aa encoded by BC001625)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MARAGPAWL LLAIWVVLPS WLSSAKVSSL IERISDPKDL KKLLRTRNNV LVLYSKSEVA AENHLRLLST VAQAVKGQGT ICWVDCGDAE SRKLCKKMKV DLSPKDKKVE LFHYQDGAFH TEYNRAVTFK SIVAFLKDPK GPPLWEEDPG AKDVVHLDSE KDFRRLLKKE EKPLLIMFYA PWCSMCKRMM PHFQKAATQL RGHAVLAGMN VYSSEFENIK EEYSVRGFPT ICYFEKGRFL FQYDNYGSTA EDIVEWLKKV WPL (1-262 aa encoded by BC001625)

Target Information

PDIR (protein disulfide isomerase-related protein) is a novel PDI protein that was originally isolated from a human placental cDNA library. It has been suggested that from its nucleotide sequence, PDIR has three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys and Cys-Pro-His-Cys), which are found in the PDI superfamily of proteins. The CXXC motif is responsible for oxidoreductase activity. PDIR is also shown to have a putative endoplasmic reticulum (ER) retention signal 'Lys-Glu-Glu-Leu' at its carboxyl terminus, indicative of ER resident proteins. Northern blot analysis of PDIR indicates that it is preferentially expressed in cells actively secreting proteins. It has also been shown that expression of PDIR is stress-inducible. Data suggest that PDIR, like other PDIs, has oxidoreductase activity of disulfide bonds and facilitates the protein folding process within the lumen of the ER.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER.

International journal of molecular sciences

Zimmermann R,Lang S,Lerner M,Förster F,Nguyen D,Helms V,Schrul B

Wed Dec 01 00:00:00 UTC 2021

Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.

The FEBS journal

Schorr S,Nguyen D,Haßdenteufel S,Nagaraj N,Cavalié A,Greiner M,Weissgerber P,Loi M,Paton AW,Paton JC,Molinari M,Förster F,Dudek J,Lang S,Helms V,Zimmermann R

Sun Nov 01 00:00:00 UTC 2020

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 UTC 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 UTC 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 UTC 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: protein disulfide isomerase A5; protein disulfide isomerase family A, member 5; protein disulfide isomerase-associated 5; Protein disulfide isomerase-related protein; Protein disulfide-isomerase A5

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Gene Aliases: 2700053F16Rik; AU015525; PDIA5; PDIR

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UniProt ID: (Human) Q14554, (Mouse) Q921X9, (Rat) Q5I0H9

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Entrez Gene ID: (Human) 10954, (Mouse) 72599, (Rat) 360722

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Function(s)

protein disulfide isomerase activity protein binding oxidoreductase activity isomerase activity

Process(es)

protein folding response to endoplasmic reticulum stress cell redox homeostasis IRE1-mediated unfolded protein response oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDIR Polyclonal Antibody

PDIR Antibody (15545-1-AP) in IHC (P)

Product Details

15545-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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