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Bioss
PDK2 Monoclonal Antibody (7E5)
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PDK2 Antibody (BSM-51043M) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Human Liver tissue; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 15 minutes; Blocking buffer (3% BSA) at room temperature for 30min; Antibody incubation with PDK2 (180CT10.2.3) Monoclonal Antibody (bsm-51043M) at 1:25 for 1 hour at 37°C, followed by a conjugated secondary antibody fo... View More
Product Details
BSM-51043M
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
7E5
Immunogen
This PDK2 monoclonal antibody is generated from mouse immunized with PDK2 recombinant protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
TBS, pH 7.4, with 1% BSA, 40% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; PDH kinase 2; pyruvate dehydrogenase; pyruvate dehydrogenase 2; Pyruvate dehydrogenase kinase isoform 2; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase kinase, isozyme 2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
Gene Aliases: PDHK2; PDK2; PDKII
UniProt ID: (Human) Q15119, (Mouse) Q9JK42
Entrez Gene ID: (Human) 5164, (Mouse) 18604
protein kinase activity
pyruvate dehydrogenase (acetyl-transferring) kinase activity
ATP binding
protein homodimerization activity
nucleotide binding
protein serine/threonine kinase activity
protein binding
kinase activity
transferase activity
protein complex binding
protein heterodimerization activity
glucose metabolic process
regulation of gluconeogenesis
protein phosphorylation
regulation of pH
insulin receptor signaling pathway
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of cellular ketone metabolic process
regulation of glucose metabolic process
cellular response to nutrient
cellular response to reactive oxygen species
glucose homeostasis
intrinsic apoptotic signaling pathway by p53 class mediator
carbohydrate metabolic process
phosphorylation
peptidyl-serine phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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