Invitrogen

PDX1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-91915

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDX1 (P52945)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.44 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806324

Product Specific Information

Positive Samples: Mouse intestine; Cellular Location: Cytoplasm, Nucleus, cytosol

Immunogen sequence: MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF

Target Information

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DLDBP; E3BP; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; IPF-1; Islet/duodenum homeobox 1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; PDHX; Somatostatin-transactivating factor 1; STF-1

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Gene Aliases: IDX-1; IPF-1; Ipf1; Mody4; pdx-1; Pdx1; STF-1

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UniProt ID: (Mouse) P52946

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Entrez Gene ID: (Mouse) 18609

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription factor binding protein complex binding sequence-specific DNA binding protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter liver development type B pancreatic cell differentiation glucose metabolic process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter smoothened signaling pathway nitric oxide mediated signal transduction multicellular organism development positive regulation of cell proliferation negative regulation of cell proliferation response to glucose regulation of gene expression positive regulation of cell death morphogenesis of embryonic epithelium insulin secretion cell differentiation pancreas development exocrine pancreas development endocrine pancreas development positive regulation of insulin secretion positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell proliferation glucose homeostasis positive regulation of DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract development stem cell differentiation detection of glucose negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of type B pancreatic cell apoptotic process
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