Invitrogen

PDX1 Recombinant Rabbit Monoclonal Antibody (JM62-45)

View all (42) PDX1 antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32790

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JM62-45

Immunogen

Synthetic peptide within Human PDX1 234-283
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2810066

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: DLDBP; E3BP; Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; Islet/duodenum homeobox-1; IUF-1; Pancreas/duodenum homeobox protein 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX-1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1

View more View less

Gene Aliases: GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; PDX1; STF-1; STF1

View more View less

UniProt ID: (Human) P52945

View more View less

Entrez Gene ID: (Human) 3651

View more View less

Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding protein complex binding protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter liver development type B pancreatic cell differentiation glucose metabolic process generation of precursor metabolites and energy transcription from RNA polymerase II promoter smoothened signaling pathway nitric oxide mediated signal transduction central nervous system development positive regulation of cell proliferation negative regulation of cell proliferation response to wounding organ morphogenesis response to iron(II) ion response to chlorate organ senescence positive regulation of cell death morphogenesis of embryonic epithelium insulin secretion exocrine pancreas development organ regeneration response to vitamin response to cytokine response to nicotine positive regulation of insulin secretion involved in cellular response to glucose stimulus response to drug glucose homeostasis response to leucine positive regulation of DNA binding positive regulation of transcription from RNA polymerase II promoter digestive tract development stem cell differentiation response to glucocorticoid detection of glucose transdifferentiation response to fatty acid negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of type B pancreatic cell apoptotic process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support