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Invitrogen
PDZK1 Recombinant Rabbit Monoclonal Antibody (5C1D3)
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Product Details
MA5-42898
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5C1D3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 420-519 of human PDZK1 (Q5T2W1).
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2912039
Product Specific Information
Positive test controls include: HepG2.
Immunogen sequence: EDVIIEVNGV NVLDEPYEKV VDRIQSSGKN VTLLVCGKKA YDYFQAKKIP IVSSLADPLD TPPDSKEGIV VESNHDSHMA KERAHSTASH SSSNSEDTEM
Target Information
PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. It may also play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. PDZK1 functions to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism and may be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-terminal linking and modulating protein; C-terminal-linking and modulating protein; CFTR-associated protein of 70 kDa; Dietary Pi-regulated RNA-1; Diphor-1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-C; NaPi-Cap1; NHERF-3; PDZ domain-containing protein 1; PDZ-containing kidney protein 1; PDZK 1; PDZK-1; Sodium-hydrogen exchanger regulatory factor 3
Gene Aliases: 1700023D20Rik; 2610507N21Rik; 4921513F16Rik; AI267131; AI314638; AL022680; CAP70; CLAMP; D3Ertd537e; Diphor1; mPDZK1; NHERF-3; NHERF3; PDZD1; PDZK1
UniProt ID: (Human) Q5T2W1, (Mouse) Q9JIL4, (Rat) Q9JJ40
Entrez Gene ID: (Human) 5174, (Mouse) 59020, (Rat) 65144
transport
cell proliferation
carnitine transport
drug transport
positive regulation of ion transmembrane transport
regulation of anion transport
positive regulation of protein targeting to membrane
establishment of protein localization to plasma membrane
cholesterol transport
intracellular transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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