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PEAR1 Antibody (PA5-112645) in ICC/IF
Immunocytochemichal analysis of PEAR1 in U251 cells using a Polyclonal antibody (Product # PA5-112645) at a dilution of 1:133. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were also counter-stained with DAPI.
Product Details
PA5-112645
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Platelet endothelial aggregation receptor 1 protein (932-1037AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2867380
Target Information
Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPEAR1; Jagged and Delta protein; Jedi; mPEAR1; Multiple EGF-like domains protein 12; multiple EGF-like-domains 12; Multiple epidermal growth factor-like domains protein 12; Platelet endothelial aggregation receptor 1; Protein Jedi; RP11-107D16.3
Gene Aliases: 3110045G13Rik; JEDI; Jedi-1; MEGF12; PEAR1; RGD1305653
UniProt ID: (Human) Q5VY43, (Mouse) Q8VIK5
Entrez Gene ID: (Human) 375033, (Mouse) 73182, (Rat) 295293
Performance Guarantee
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