Proteintech

PEDF Polyclonal Antibody

FIGURE: 1 / 1

PEDF Antibody (26045-1-AP) in WB

A375 cells were subjected to SDS PAGE followed by western blot with 26045-1-AP ( PEDF antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Product Details

26045-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PEDF Fusion Protein Ag23296 (87-418 aa encoded by BC013984)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TALSALSLG AEQRTESIIH RALYYDLISS PDIHGTYKEL LDTVTARQKN LKSASRIVFE KKLRIKSSFV APLEKSYGTR PRVLTGNPRL DLQEINNWVQ AQMKGKLARS TKEIPDEISI LLLGVAHFKG QWVTKFDSRK TSLEDFYLDE ERTVRVPMMS DPKAVLRYGL DSDLSCKIAQ LPLTGSMSII FFLPLKVTQN LTLIEESLTS EFIHDIDREL KTVQAVLTVP KLKLSYEGEV TKSLQEMKLQ SLFDSPDFSK ITGKPIKLTQ VEHRAGFEWN EDGAGTTPSP GLQPAHLTFP LDYHLNQPFI FVLRDTDTGA LLFIGKILDP RGP (87-418 aa encoded by BC013984)

Target Information

PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.

Journal of cellular and molecular medicine

Li L,Cao X,Huang L,Huang X,Gu J,Yu X,Zhu Y,Zhou Y,Song Y,Zhu M

Mon May 01 00:00:00 UTC 2023

Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.

Journal of cellular and molecular medicine

Li L,Cao X,Huang L,Huang X,Gu J,Yu X,Zhu Y,Zhou Y,Song Y,Zhu M

Mon May 01 00:00:00 UTC 2023

Strategies to Attenuate Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Pigment Epithelium-Derived Factor.

Human gene therapy

Zhang H,Li Z,Quan X,Liu X,Sun T,Wei T,Pan J,Liu Z,Wang M,Dong H,Zhang Z

Tue Mar 01 00:00:00 UTC 2022

TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway.

Cell death & disease

Fu X,Zhang H,Chen Z,Yang Z,Shi D,Liu T,Chen W,Yao F,Su X,Deng W,Chen M,Yang A

Tue May 21 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Cell proliferation-inducing gene 35 protein; EPC 1; EPC-1; EPC1; PEDF; PIG 35; Pigment epithelium-derived factor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Serpin F1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SERPINF 1; sserpin family F member 1; testis tissue sperm-binding protein Li 70n

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Gene Aliases: EPC-1; OI12; OI6; PEDF; PIG35; SERPINF1

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UniProt ID: (Human) P36955

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Entrez Gene ID: (Human) 5176

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Function(s)

serine-type endopeptidase inhibitor activity protein binding

Process(es)

kidney development multicellular organism development aging short-term memory cell proliferation response to acidic pH negative regulation of endothelial cell migration negative regulation of gene expression negative regulation of endopeptidase activity positive regulation of neuron projection development negative regulation of angiogenesis ovulation cycle response to arsenic-containing substance negative regulation of inflammatory response positive regulation of neurogenesis retina development in camera-type eye negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to cobalt ion cellular response to retinoic acid cellular response to glucose stimulus cellular response to dexamethasone stimulus negative regulation of neuron death

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PEDF Polyclonal Antibody

PEDF Antibody (26045-1-AP) in WB

Product Details

26045-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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