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Proteintech
PELI1 Polyclonal Antibody
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Product Details
12053-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PELI1 Fusion Protein Ag2683 (294-418 aa encoded by BC011419)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody may cross react with Pellino-3.
Immunogen sequence: MKRKDVVDE KQPWVYLNCG HVHGYHNWGN KEERDGKDRE CPMCRSVGPY VPLWLGCEAG FYVDAGPPTH AFSPCGHVCS EKTTAYWSQI PLPHGTHTFH AACPFCAHQL AGEQGYIRLI FQGPLD (294-418 aa encoded by BC011419)
Target Information
The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase pellino homolog 1; pellino 1; pellino homolog 1; Pellino-1; Pellino-related intracellular-signaling molecule; pellino1; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1
Gene Aliases: 2810468L03Rik; A930031K15Rik; AA409794; AI586297; D11Ertd676e; PELI1; PRISM
UniProt ID: (Human) Q96FA3, (Mouse) Q8C669
Entrez Gene ID: (Human) 57162, (Mouse) 67245, (Rat) 305549
protein binding
ligase activity
ubiquitin-ubiquitin ligase activity
ubiquitin-protein transferase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
ubiquitin protein ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
molecular_function
protein polyubiquitination
positive regulation of cytokine production
Toll signaling pathway
positive regulation of B cell proliferation
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
response to lipopolysaccharide
positive regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
negative regulation of T cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to dsRNA
negative regulation of T cell activation
positive regulation of B cell activation
protein K48-linked ubiquitination
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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