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PEN2 Antibody (BS-6456R) in IHC (P)
Formalin-fixed and paraffin-embedded rat brain labeled with Anti-PEN2 Polyclonal Antibody, Unconjugated(bs-6456R) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C.
Product Details
BS-6456R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PEN2, amino acids 6-80.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; Liver regeneration-related protein LRRGT00140; LRRGT00140 mRNA; presenilin enhancer 2 homolog; presenilin enhancer gamma secretase subunit; Presenilin enhancer protein 2
Gene Aliases: 1700023M09Rik; MDS033; MSTP064; PEN-2; PEN2; PSENEN; RGD1312037
UniProt ID: (Human) Q9NZ42, (Mouse) Q9CQR7, (Rat) Q6QI68
Entrez Gene ID: (Human) 55851, (Mouse) 66340, (Rat) 292788
membrane protein ectodomain proteolysis
Notch signaling pathway
Notch receptor processing
protein processing
membrane protein intracellular domain proteolysis
amyloid precursor protein catabolic process
positive regulation of apoptotic process
positive regulation of catalytic activity
ephrin receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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