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This antibody has primarily been tested in HA-PEN2 transfected cells combining Immunoprecipitation with Western blot analysis (ECL).
For endogenous sample testing, it is suggested that the investigator load a greater amount of protein on the gel.
Suggested positive control: antigen standard for PSENEN (transient overexpression lysate).
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; presenilin enhancer 2 homolog; presenilin enhancer gamma secretase subunit; Presenilin enhancer protein 2
Gene Aliases: 1700023M09Rik; MDS033; MSTP064; PEN-2; PEN2; PSENEN
UniProt ID: (Human) Q9NZ42, (Mouse) Q9CQR7
Entrez Gene ID: (Human) 55851, (Mouse) 66340
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