Proteintech

PER1 Polyclonal Antibody

PER1 Antibody in Immunocytochemistry (ICC/IF)

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PER1 Antibody (13463-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using PER1 antibody 13463-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

PER1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

13463-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PER1 Fusion Protein Ag4249 (1-341 aa encoded by BC028207)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSGPLEGAD GGGDPRPGES FCPGGVPSPG PPQHRPCPGP SLADDTDANS NGSSGNESNG HESRGASQRS SHSSSSGNGK DSALLETTES SKSTNSQSPS PPSSSIAYSL LSASSEQDNP STSGCSSEQS ARARTQKELM TALRELKLRL PPERRGKGRS GTLATLQYAL ACVKQVQANQ EYYQQWSLEE GEPCSMDMST YTLEELEHIT SEYTLQNQDT FSVAVSFLTG RIVYISEQAA VLLRCKRDVF RGTRFSELLA PQDVGVFYGS TAPSRLPTWG TGASAGSGLR DFTQEKSVFC RIRGGPDRDP GPRYQPFRLT PYVTKIRVSD GAPAQPCCLL IAE (1-341 aa encoded by BC028207)

Target Information

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PER1 promotes functional recovery of mice with hindlimb ischemia by inducing anti-inflammatory macrophage polarization.

Biochemical and biophysical research communications

Ding Y,Wan S,Ma L,Wei K,Ye K

Sun Feb 12 00:00:00 UTC 2023

PER1 promotes functional recovery of mice with hindlimb ischemia by inducing anti-inflammatory macrophage polarization.

Biochemical and biophysical research communications

Ding Y,Wan S,Ma L,Wei K,Ye K

Sun Feb 12 00:00:00 UTC 2023

CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice.

iScience

Chen M,Zhang Y,Zeng S,Li D,You M,Zhang M,Wang Z,Wei L,Chen Y,Ruan XZ

Fri Apr 21 00:00:00 UTC 2023

Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium.

Anesthesia and analgesia

Dulko E,Jedrusiak M,Osuru HP,Atluri N,Illendula M,Davis EM,Beenhakker MP,Lunardi N

Sat Jul 01 00:00:00 UTC 2023

The association between disruption of the circadian rhythm and aggravation of colitis in mice.

Gastroenterology report

Chen YD,Zhao RF,Zheng G,Ling FM,Li JR,Xu MY,Guo D,Zhang QL,Li S,Zhu LR

Sat Jul 16 00:00:00 UTC 2022

Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model.

Theranostics

Naven MA,Zeef LAH,Li S,Humphreys PA,Smith CA,Pathiranage D,Cain S,Woods S,Bates N,Au M,Wen C,Kimber SJ,Meng QJ

Wed Jun 08 00:00:00 UTC 2022

Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.

Journal of agricultural and food chemistry

Li R,Xiao J,Cao Y,Huang Q,Ho CT,Lu M

Wed Jan 26 00:00:00 UTC 2022

hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.

Cell death & disease

Wan X,Zhu L,Zhao L,Peng L,Xiong J,Yang W,Yuan J,Liang F,Zhang K,Chen K

Fri Mar 19 00:00:00 UTC 2021

Angptl8 mediates food-driven resetting of hepatic circadian clock in mice.

Nature communications

Chen S,Feng M,Zhang S,Dong Z,Wang Y,Zhang W,Liu C

Tue Aug 06 00:00:00 UTC 2019

Loss of circadian protein TIMELESS accelerates the progression of cellular senescence.

Biochemical and biophysical research communications

Shen X,Li M,Mao Z,Yu W

Tue Sep 18 00:00:00 UTC 2018

Loss of circadian protein TIMELESS accelerates the progression of cellular senescence.

Biochemical and biophysical research communications

Shen X,Li M,Mao Z,Yu W

Tue Sep 18 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui; hPER1; mPER1; per1 {ECO:0000312|RGD:727863}; period 1; Period circadian protein homolog 1; period homolog 1; Period, drosophila, homolog of; rPER1

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Gene Aliases: hPER; KIAA0482; m-rigui; mPer1; PER; PER1; RIGUI; rper1

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UniProt ID: (Human) O15534, (Mouse) O35973, (Rat) Q8CHI5

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Entrez Gene ID: (Human) 5187, (Mouse) 18626, (Rat) 287422

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, transcription factor binding transcription factor binding kinase binding chromatin DNA binding ubiquitin protein ligase binding E-box binding transcription regulatory region sequence-specific DNA binding signal transducer activity protein binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter regulation of sodium ion transport transcription, DNA-templated regulation of transcription, DNA-templated signal transduction circadian rhythm posttranscriptional regulation of gene expression circadian regulation of gene expression regulation of hair cycle regulation of circadian rhythm negative regulation of I-kappaB kinase/NF-kappaB signaling entrainment of circadian clock by photoperiod histone H3 acetylation histone H4 acetylation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade rhythmic process response to cAMP histone H3 deacetylation circadian regulation of translation regulation of cytokine production involved in inflammatory response regulation of p38MAPK cascade negative regulation of glucocorticoid receptor signaling pathway entrainment of circadian clock

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PER1 Polyclonal Antibody

PER1 Antibody (13463-1-AP) in ICC/IF

Product Details

13463-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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