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Invitrogen
PER2 Polyclonal Antibody
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PER2 Antibody (PA5-78264) in IHC (P)
PER2 Polyclonal Antibody detects PER2 protein expression by immunohistochemical analysis. Sample: Paraffin-Embedded adult mouse retina. Green: PER2 protein stained by PER2 Polyclonal Antibody (Product # PA5-78264) diluted at 1:250. Red: beta Tubulin 3/ TUJ1, stained by beta Tubulin 3/ TUJ1 antibody [GT11710] diluted at 1:250. Blue: Fluoroshield with DAPI. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-78264
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human PER2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736339
Product Specific Information
Positive Control: human Per2-transfected 293T
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PER2, also known as Period circadian protein homolog 2, is a mainly nuclear protein that shows nucleocytoplasmic shuttling which is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. PER2 belongs to the basic helix-loop-helix family of transcription factors and contains a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. PER2 is a component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. This protein is thus essential for generating circadian rhythms and is a negative element in the circadian transcriptional loop which influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Expression of PER2 is fairly wide spread with strong expression in skeletal muscle and pancreas and slight expression in lung. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Circadian clock protein PERIOD 2; hPER2; period 2; period circadian protein 2; Period circadian protein homolog 2; period homolog 2
Gene Aliases: FASPS; FASPS1; KIAA0347; PER2
UniProt ID: (Human) O15055
Entrez Gene ID: (Human) 8864
negative regulation of transcription from RNA polymerase II promoter
response to ischemia
glycogen biosynthetic process
gluconeogenesis
transcription, DNA-templated
fatty acid metabolic process
circadian rhythm
regulation of vasoconstriction
lactate biosynthetic process
negative regulation of protein ubiquitination
circadian regulation of gene expression
regulation of circadian rhythm
negative regulation of circadian rhythm
negative regulation of transcription, DNA-templated
regulation of neurogenesis
regulation of insulin secretion
white fat cell differentiation
regulation of cell cycle
regulation of glutamate uptake involved in transmission of nerve impulse
negative regulation of fat cell proliferation
histone H3 deacetylation
circadian regulation of translation
negative regulation of transcription regulatory region DNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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