Proteintech

PEX1 Polyclonal Antibody

PEX1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

PEX1 Antibody (13669-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 13669-1-AP (PEX1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

PEX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

13669-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PEX1 Fusion Protein Ag4623 (927-1283 aa encoded by BC035575)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IRAQAAKPC ILFFDEFESI APRRGHDNTG VTDRVVNQLL TQLDGVEGLQ GVYVLAATSR PDLIDPALLR PGRLDKCVYC PPPDQVSRLE ILNVLSDSLP LADDVDLQHV ASVTDSFTGA DLKALLYNAQ LEALHGMLLS SGLQDGSSSS DSDLSLSSMV FLNHSSGSDD SAGDGECGLD QSLVSLEMSE ILPDESKFNM YRLYFGSSYE SELGNGTSSD LSSQCLSAPS SMTQDLPGVP GKDQLFSQPP VLRTASQEGC QELTQEQRDQ LRADISIIKG RYRSQSGEDE SMNQPGPIKT RLAISQSHLM TALGHTRPSI SEDDWKNFAE LYESFQNPKR RKNQSGTMFR PGQKVTLA (927-1283 aa encoded by BC035575)

Target Information

This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis.

Biological chemistry

Ott J,Sehr J,Schmidt N,Schliebs W,Erdmann R

Thu Feb 23 00:00:00 UTC 2023

Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear Synaptopathy and Hearing Loss.

Cells

Mauriac SA,Peineau T,Zuberi A,Lutz C,Géléoc GSG

Fri Dec 09 00:00:00 UTC 2022

AAV-mediated PEX1 gene augmentation improves visual function in the PEX1-Gly844Asp mouse model for mild Zellweger spectrum disorder.

Molecular therapy. Methods & clinical development

Argyriou C,Polosa A,Song JY,Omri S,Steele B,Cécyre B,McDougald DS,Di Pietro E,Bouchard JF,Bennett J,Hacia JG,Lachapelle P,Braverman NE

Fri Dec 10 00:00:00 UTC 2021

Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell.

PloS one

Mu Y,Maharjan Y,Kumar Dutta R,Wei X,Kim JH,Son J,Park C,Park R

Tue Jul 27 00:00:00 UTC 2021

Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.

The EMBO journal

Miyamoto T,Hosoba K,Itabashi T,Iwane AH,Akutsu SN,Ochiai H,Saito Y,Yamamoto T,Matsuura S

Wed Jun 17 00:00:00 UTC 2020

Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.

The EMBO journal

Miyamoto T,Hosoba K,Itabashi T,Iwane AH,Akutsu SN,Ochiai H,Saito Y,Yamamoto T,Matsuura S

Wed Jun 17 00:00:00 UTC 2020

Zellweger spectrum disorder patient-derived fibroblasts with the PEX1-Gly843Asp allele recover peroxisome functions in response to flavonoids.

Journal of cellular biochemistry

MacLean GE,Argyriou C,Di Pietro E,Sun X,Birjandian S,Saberian P,Hacia JG,Braverman NE

Fri Mar 01 00:00:00 UTC 2019

Zellweger spectrum disorder patient-derived fibroblasts with the PEX1-Gly843Asp allele recover peroxisome functions in response to flavonoids.

Journal of cellular biochemistry

MacLean GE,Argyriou C,Di Pietro E,Sun X,Birjandian S,Saberian P,Hacia JG,Braverman NE

Fri Mar 01 00:00:00 UTC 2019

A longitudinal study of retinopathy in the PEX1-Gly844Asp mouse model for mild Zellweger Spectrum Disorder.

Experimental eye research

Argyriou C,Polosa A,Cecyre B,Hsieh M,Di Pietro E,Cui W,Bouchard JF,Lachapelle P,Braverman N

Sun Sep 01 00:00:00 UTC 2019

A longitudinal study of retinopathy in the PEX1-Gly844Asp mouse model for mild Zellweger Spectrum Disorder.

Experimental eye research

Argyriou C,Polosa A,Cecyre B,Hsieh M,Di Pietro E,Cui W,Bouchard JF,Lachapelle P,Braverman N

Sun Sep 01 00:00:00 UTC 2019

AKT-mediated phosphorylation of ATG4B impairs mitochondrial activity and enhances the Warburg effect in hepatocellular carcinoma cells.

Autophagy

Ni Z,He J,Wu Y,Hu C,Dai X,Yan X,Li B,Li X,Xiong H,Li Y,Li S,Xu L,Li Y,Lian J,He F

Thu Mar 07 00:00:00 UTC 2019

AKT-mediated phosphorylation of ATG4B impairs mitochondrial activity and enhances the Warburg effect in hepatocellular carcinoma cells.

Autophagy

Ni Z,He J,Wu Y,Hu C,Dai X,Yan X,Li B,Li X,Xiong H,Li Y,Li S,Xu L,Li Y,Lian J,He F

Thu Mar 07 00:00:00 UTC 2019

A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.

Cell death discovery

Flor AC,Wolfgeher D,Wu D,Kron SJ

Wed Sep 30 00:00:00 UTC 2020

A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.

Cell death discovery

Flor AC,Wolfgeher D,Wu D,Kron SJ

Wed Sep 30 00:00:00 UTC 2020

Spectrum of PEX1 and PEX6 variants in Heimler syndrome.

European journal of human genetics : EJHG

Smith CE,Poulter JA,Levin AV,Capasso JE,Price S,Ben-Yosef T,Sharony R,Newman WG,Shore RC,Brookes SJ,Mighell AJ,Inglehearn CF

Tue Nov 01 00:00:00 UTC 2016

Spectrum of PEX1 and PEX6 variants in Heimler syndrome.

European journal of human genetics : EJHG

Smith CE,Poulter JA,Levin AV,Capasso JE,Price S,Ben-Yosef T,Sharony R,Newman WG,Shore RC,Brookes SJ,Mighell AJ,Inglehearn CF

Tue Nov 01 00:00:00 UTC 2016

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

Autophagy

Nordgren M,Francisco T,Lismont C,Hennebel L,Brees C,Wang B,Van Veldhoven PP,Azevedo JE,Fransen M

Mon Jun 20 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Peroxin-1; Peroxisomal ATPase PEX1; Peroxisome biogenesis disorder protein 1; Peroxisome biogenesis factor 1; Zellweger syndrome

View more View less

Gene Aliases: 5430414H02Rik; E330005K07Rik; HMLR1; PBD1A; PBD1B; PEX1; RGD1559939; ZWS; ZWS1

View more View less

UniProt ID: (Human) O43933, (Mouse) Q5BL07

View more View less

Entrez Gene ID: (Human) 5189, (Rat) 500006, (Mouse) 71382

View more View less

Function(s)

protein binding ATP binding protein C-terminus binding protein complex binding ATPase activity, coupled molecular_function nucleotide binding lipid binding

Process(es)

protein targeting to peroxisome peroxisome organization biological_process metabolic process protein import into peroxisome matrix microtubule-based peroxisome localization transport protein transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

PEX1 Polyclonal Antibody

PEX1 Antibody (13669-1-AP) in ICC/IF

Product Details

13669-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!