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Proteintech
PEX5 Polyclonal Antibody
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Product Details
12545-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PEX5 Fusion Protein Ag3268 (340-639 aa encoded by BC010621)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes endogenous PEX5, which migrates with an apparent molecular mass of 80 kDa.
Immunogen sequence: EGDLPNAVL LFEAAVQQDP KHMEAWQYLG TTQAENEQEL LAISALRRCL ELKPDNQTAL MALAVSFTNE SLQRQACETL RDWLRYTPAY AHLVTPAEEG AGGAGLGPSK RILGSLLSDS LFLEVKELFL AAVRLDPTSI DPDVQCGLGV LFNLSGEYDK AVDCFTAALS VRPNDYLLWN KLGATLANGN QSEEAVAAYR RALELQPGYI RSRYNLGISC INLGAHREAV EHFLEALNMQ RKSRGPRGEG GAMSENIWST LRLALSMLGQ SDAYGAADAR DLSTLLTMFG LPQ (340-639 aa encoded by BC010621)
Target Information
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: peroxin 5; Peroxin-5; peroxisomal biogenesis factor 5; Peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 (SKL type) receptor; Peroxisomal targeting signal 1 receptor; peroxisomal targeting signal import receptor; peroxisomal targeting signal receptor 1; peroxisome biogenesis factor 5; Peroxisome receptor 1; PTS1 BP; PTS1 receptor; PTS1-BP; PXR1P
Gene Aliases: AW212715; ESTM1; PBD2A; PBD2B; PEX5; Pex5_predicted; PTS1-BP; PTS1R; PXR1; RCDP5; X83306
UniProt ID: (Human) P50542, (Mouse) O09012, (Rat) Q2M2R8
Entrez Gene ID: (Human) 5830, (Mouse) 19305, (Rat) 312703
protein import into peroxisome matrix
protein import into peroxisome matrix, docking
protein import into peroxisome membrane
negative regulation of protein homotetramerization
very long-chain fatty acid metabolic process
neuron migration
protein targeting to peroxisome
fatty acid beta-oxidation
transport
mitochondrion organization
mitochondrial membrane organization
endoplasmic reticulum organization
peroxisome organization
isoprenoid biosynthetic process
protein transport
protein import into peroxisome matrix, translocation
cerebral cortex cell migration
cerebral cortex neuron differentiation
positive regulation of multicellular organism growth
cellular lipid metabolic process
cell development
neuromuscular process
protein tetramerization
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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