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Product Details
PGCF-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase F protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
GUCY2F (Guanylate cyclase 2F, retinal) is also named as GUC2F, RETGC2 and belongs to the adenylyl cyclase class-4/guanylyl cyclase family. GUCY2F may play a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. By in situ hybridization, mRNA encoding GUCY2F is found only in the outer nuclear layer and inner segments of photoreceptor cells. By using synthetic peptide antiserum specific for each RetGC subtype, RetGC-2(GUCY2F) can be distinguished from RetGC-1 as a slightly smaller protein in immunoblots of bovine rod outer segments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GC-F; guanylate cyclase 2D-like, membrane (retina-specific); Guanylate cyclase 2F; Guanylate cyclase 2F, retinal; Guanylate cyclase F; RETGC-2; Retinal guanylyl cyclase 2; Rod outer segment membrane guanylate cyclase 2; ROS-GC2
Gene Aliases: A930002I06; CYGF; GC-F; GC2; GUC2DL; GUC2F; GUCY2F; RETGC-2; RETGC2; ROS-GC2
UniProt ID: (Human) P51841, (Mouse) Q5SDA5, (Rat) P51842
Entrez Gene ID: (Human) 2986, (Mouse) 245650, (Rat) 116556
adenylate cyclase activity
guanylate cyclase activity
protein kinase activity
receptor activity
ATP binding
GTP binding
protein homodimerization activity
protein heterodimerization activity
nucleotide binding
transferase activity, transferring phosphorus-containing groups
lyase activity
phosphorus-oxygen lyase activity
protein binding
cGMP biosynthetic process
protein phosphorylation
receptor guanylyl cyclase signaling pathway
visual perception
regulation of rhodopsin mediated signaling pathway
intracellular signal transduction
detection of light stimulus involved in visual perception
cyclic nucleotide biosynthetic process
response to stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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