Proteintech

PGD Polyclonal Antibody

PGD Antibody in Immunocytochemistry (ICC/IF)

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PGD Antibody (14718-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 14718-1-AP (PGD antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

PGD Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PGD Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14718-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:300-1:1200

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PGD Fusion Protein Ag6444 (137-483 aa encoded by BC000368)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YGPSLMPGG NKEAWPHIKT IFQGIAAKVG TGEPCCDWVG DEGAGHFVKM VHNGIEYGDM QLICEAYHLM KDVLGMAQDE MAQAFEDWNK TELDSFLIEI TANILKFQDT DGKHLLPKIR DSAGQKGTGK WTAISALEYG VPVTLIGEAV FARCLSSLKD ERIQASKKLK GPQKFQFDGD KKSFLEDIRK ALYASKIISY AQGFMLLRQA ATEFGWTLNY GGIALMWRGG CIIRSVFLGK IKDAFDRNPE LQNLLLDDFF KSAVENCQDS WRRAVSTGVQ AGIPMPCFTT ALSFYDGYRH EMLPASLIQA QRDYFGAHTY ELLAKPGQFI HTNWTGHGGT VSSSSYNA (137-483 aa encoded by BC000368)

Target Information

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification of novel immune subtypes and potential hub genes of patients with psoriasis.

Journal of translational medicine

Li Y,Li L,Tian Y,Luo J,Huang J,Zhang L,Zhang J,Li X,Hu L

Wed Mar 08 00:00:00 UTC 2023

Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation.

Molecular cancer research : MCR

Qiao R,Wei M,Chen H,Zhang X,Zhang J,Gao L,Ma H,Wang Y,Li L

Tue Aug 01 00:00:00 UTC 2023

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Journal of immunology (Baltimore, Md. : 1950)

Fan TW,Daneshmandi S,Cassel TA,Uddin MB,Sledziona J,Thompson PT,Lin P,Higashi RM,Lane AN

Tue Nov 01 00:00:00 UTC 2022

Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.

Annals of hepatology

Cook JJ,Wei M,Segovia B,Cosio-Lima L,Simpson J,Taylor S,Koh Y,Kim S,Lee Y

Thu Jul 07 00:00:00 UTC 2022

Spatial region-resolved proteome map reveals mechanism of COVID-19-associated heart injury.

Cell reports

Leng L,Ma J,Zhang PP,Xu SC,Li X,Jin Y,Cai J,Tang R,Zhao L,He ZC,Li MS,Zhang H,Zhou LR,Wu ZH,Li TR,Zhu YP,Wang YJ,Wu HB,Ping YF,Yao XH,Zhu CH,Guo HT,Tan LY,Liang ZY,Bian XW,Zhang SY

Tue Jun 14 00:00:00 UTC 2022

Mitochondrial NADP⁺ is essential for proline biosynthesis during cell growth.

Nature metabolism

Tran DH,Kesavan R,Rion H,Soflaee MH,Solmonson A,Bezwada D,Vu HS,Cai F,Phillips JA,DeBerardinis RJ,Hoxhaj G

Thu Apr 01 00:00:00 UTC 2021

Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.

The Journal of investigative dermatology

Gu Z,Zhang H,Guo X,Cao Y

Sat Aug 01 00:00:00 UTC 2020

iTRAQ-Based Proteomics Reveals Potential Anti-Virulence Targets for ESBL-Producing Klebsiella pneumoniae.

Infection and drug resistance

Wang Y,Cong S,Zhang Q,Li R,Wang K

Sat Apr 16 00:00:00 UTC 2022

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Carcinogenesis

Sheng H,Li Z,Su S,Sun W,Zhang X,Li L,Li J,Liu S,Lu B,Zhang S,Shan C

Fri Jul 10 00:00:00 UTC 2020

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Carcinogenesis

Sheng H,Li Z,Su S,Sun W,Zhang X,Li L,Li J,Liu S,Lu B,Zhang S,Shan C

Fri Jul 10 00:00:00 UTC 2020

SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose-derived mesenchymal stem cells via metabolic switching.

Clinical and translational medicine

Ou T,Yang W,Li W,Lu Y,Dong Z,Zhu H,Sun X,Dong Z,Weng X,Chang S,Li H,Li Y,Qiu Z,Hu K,Sun A,Ge J

Tue Sep 01 00:00:00 UTC 2020

Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.

Biochemical pharmacology

Feng Q,Li X,Sun W,Sun M,Li Z,Sheng H,Xie F,Zhang S,Shan C

Sat Aug 01 00:00:00 UTC 2020

mTOR Overcomes Multiple Metabolic Restrictions to Enable HIV-1 Reverse Transcription and Intracellular Transport.

Cell reports

Taylor HE,Calantone N,Lichon D,Hudson H,Clerc I,Campbell EM,D'Aquila RT

Tue Jun 23 00:00:00 UTC 2020

The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.

iScience

Sinha T,Naash MI,Al-Ubaidi MR

Fri Apr 24 00:00:00 UTC 2020

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.

Cell reports

Sun Y,Bandi M,Lofton T,Smith M,Bristow CA,Carugo A,Rogers N,Leonard P,Chang Q,Mullinax R,Han J,Shi X,Seth S,Meyers BA,Miller M,Miao L,Ma X,Feng N,Giuliani V,Geck Do M,Czako B,Palmer WS,Mseeh F,Asara JM,Jiang Y,Morlacchi P,Zhao S,Peoples M,Tieu TN,Warmoes MO,Lorenzi PL,Muller FL,DePinho RA,Draetta GF,Toniatti C,Jones P,Heffernan TP,Marszalek JR

Tue Jan 08 00:00:00 UTC 2019

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.

Cell reports

Tue Jan 08 00:00:00 UTC 2019

Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.

Nature communications

Liu R,Li W,Tao B,Wang X,Yang Z,Zhang Y,Wang C,Liu R,Gao H,Liang J,Yang W

Fri Mar 01 00:00:00 UTC 2019

Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.

Nature communications

Ma X,Wang L,Huang D,Li Y,Yang D,Li T,Li F,Sun L,Wei H,He K,Yu F,Zhao D,Hu L,Xing S,Liu Z,Li K,Guo J,Yang Z,Pan X,Li A,Shi Y,Wang J,Gao P,Zhang H

Wed Nov 15 00:00:00 UTC 2017

Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.

Nature communications

Ma X,Wang L,Huang D,Li Y,Yang D,Li T,Li F,Sun L,Wei H,He K,Yu F,Zhao D,Hu L,Xing S,Liu Z,Li K,Guo J,Yang Z,Pan X,Li A,Shi Y,Wang J,Gao P,Zhang H

Wed Nov 15 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: 6-phosphogluconate dehydrogenase, decarboxylating; 6-phosphogluconate dehydrogenase, decarboxylating-like

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Gene Aliases: 0610042A05Rik; 6PGD; AU019875; C78335; PGD; PGDH

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UniProt ID: (Rat) P85968, (Human) P52209, (Mouse) Q9DCD0

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Entrez Gene ID: (Rat) 100360180, (Human) 5226, (Mouse) 110208

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Function(s)

phosphogluconate dehydrogenase (decarboxylating) activity phosphogluconate 2-dehydrogenase activity oxidoreductase activity carbohydrate binding carboxylic acid binding NADP binding

Process(es)

carbohydrate metabolic process pentose-phosphate shunt NADP metabolic process pentose-phosphate shunt, oxidative branch pentose biosynthetic process D-gluconate metabolic process oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PGD Polyclonal Antibody

PGD Antibody (14718-1-AP) in ICC/IF

Product Details

14718-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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