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PGM1 Polyclonal Antibody

PGM1 Antibody in Immunocytochemistry (ICC/IF)

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PGM1 Antibody (15161-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using PGM1 antibody 15161-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

PGM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PGM1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15161-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PGM1 Fusion Protein Ag7269 (213-562 aa encoded by BC001756)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SGPNRLKIC IDAMHGVVGP YVKKILCEEL GAPANSAVNC VPLEDFGGHH PDPNLTYAAD LVETMKSGEH DFGAAFDGDG DRNMILGKHG FFVNPSDSVA VIAANIFSIP YFQQTGVRGF ARSMPTSGAL DRVASATKIA LYETPTGWKF FGNLMDASKL SLCGEESFGT GSDHIREKDG LWAVLAWLSI LATRKQSVED ILKDHWQKHG RNFFTRYDYE EVEAEGANKM MKDLEALMFD RSFVGKQFSA NDKVYTVEKA DNFEYSDPVD GSISRNQGLR LIFTDGSRIV FRLSGTGSAG ATIRLYIDSY EKDVAKINQD PQVMLAPLIS IALKVSQLQE RTGRTAPTVI T (213-562 aa encoded by BC001756)

Target Information

Phosphoglucomutases (PGM; EC 5.4.2.2) catalyze the transfer of phosphate between the 1 and 6 positions of glucose. Isozymes of PGM are monomeric, with molecular masses of about 60 kD, and are encoded by several genes, including PGM1. In most cell types, PGM1 isozymes predominate, representing about 90% of total PGM activity. One exception is red cells, where PGM2 (MIM 172000) is a major isozyme (Putt et al., 1993 [PubMed 8257433]). [supplied by OMIM].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Knock-down of PGM1 inhibits cell viability, glycolysis, and oxidative phosphorylation in glioma under low glucose condition via the Myc signaling pathway.

Biochemical and biophysical research communications

Liu S,Deng Y,Yu Y,Xia X

Sun May 14 00:00:00 UTC 2023

Lactate metabolism is essential in early-onset mitochondrial myopathy.

Science advances

Chen Z,Bordieanu B,Kesavan R,Lesner NP,Venigalla SSK,Shelton SD,DeBerardinis RJ,Mishra P

Wed Jan 04 00:00:00 UTC 2023

Integrative proteomics and metabolomics approach to elucidate metabolic dysfunction induced by silica nanoparticles in hepatocytes.

Journal of hazardous materials

Zhu Y,Zhang Y,Li Y,Guo C,Fan Z,Li Y,Yang M,Zhou X,Sun Z,Wang J

Fri Jul 15 00:00:00 UTC 2022

MYCT1 alters the glycogen shunt by regulating selective translation of RACK1-mediated enzymes.

iScience

Ding DX,Wang Y,Yan W,Fu WN

Fri Mar 18 00:00:00 UTC 2022

Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma.

Frontiers in cell and developmental biology

Zhang W,Lyu P,Andreev D,Jia Y,Zhang F,Bozec A

Tue Jan 03 00:00:00 UTC 2023

PGM1 suppresses colorectal cancer cell migration and invasion by regulating the PI3K/AKT pathway.

Cancer cell international

Zheng Z,Zhang X,Bai J,Long L,Liu D,Zhou Y

Wed May 25 00:00:00 UTC 2022

Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts.

Neurobiology of aging

Gerou M,Hall B,Woof R,Allsop J,Kolb SJ,Meyer K,Shaw PJ,Allen SP

Wed Sep 01 00:00:00 UTC 2021

Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis.

Cancer letters

Chen X,Li Z,Yong H,Wang W,Wang D,Chu S,Li M,Hou P,Zheng J,Bai J

Mon Jun 28 00:00:00 UTC 2021

Neointimal hyperplasia in the inferior vena cava of adenine-induced chronic kidney disease rats with aortocaval fistulas.

Clinical and experimental nephrology

Du J,Liang L,Liu S,Yang X,Cao S,Zhang H,Su H,Gong X,Chen Q,Kong X,Xu D

Sun Nov 01 00:00:00 UTC 2020

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.

Cell metabolism

Curtis M,Kenny HA,Ashcroft B,Mukherjee A,Johnson A,Zhang Y,Helou Y,Batlle R,Liu X,Gutierrez N,Gao X,Yamada SD,Lastra R,Montag A,Ahsan N,Locasale JW,Salomon AR,Nebreda AR,Lengyel E

Tue Jan 08 00:00:00 UTC 2019

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.

Cell metabolism

Curtis M,Kenny HA,Ashcroft B,Mukherjee A,Johnson A,Zhang Y,Helou Y,Batlle R,Liu X,Gutierrez N,Gao X,Yamada SD,Lastra R,Montag A,Ahsan N,Locasale JW,Salomon AR,Nebreda AR,Lengyel E

Tue Jan 08 00:00:00 UTC 2019

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.

Cell metabolism

Curtis M,Kenny HA,Ashcroft B,Mukherjee A,Johnson A,Zhang Y,Helou Y,Batlle R,Liu X,Gutierrez N,Gao X,Yamada SD,Lastra R,Montag A,Ahsan N,Locasale JW,Salomon AR,Nebreda AR,Lengyel E

Tue Jan 08 00:00:00 UTC 2019

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.

Cell metabolism

Curtis M,Kenny HA,Ashcroft B,Mukherjee A,Johnson A,Zhang Y,Helou Y,Batlle R,Liu X,Gutierrez N,Gao X,Yamada SD,Lastra R,Montag A,Ahsan N,Locasale JW,Salomon AR,Nebreda AR,Lengyel E

Tue Jan 08 00:00:00 UTC 2019

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD⁺ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.

Cell reports

Elhassan YS,Kluckova K,Fletcher RS,Schmidt MS,Garten A,Doig CL,Cartwright DM,Oakey L,Burley CV,Jenkinson N,Wilson M,Lucas SJE,Akerman I,Seabright A,Lai YC,Tennant DA,Nightingale P,Wallis GA,Manolopoulos KN,Brenner C,Philp A,Lavery GG

Tue Aug 13 00:00:00 UTC 2019

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Brain : a journal of neurology

Allen SP,Hall B,Woof R,Francis L,Gatto N,Shaw AC,Myszczynska M,Hemingway J,Coldicott I,Willcock A,Job L,Hughes RM,Boschian C,Bayatti N,Heath PR,Bandmann O,Mortiboys H,Ferraiuolo L,Shaw PJ

Sun Dec 01 00:00:00 UTC 2019

A novel congenital disorder of glycosylation type without central nervous system involvement caused by mutations in the phosphoglucomutase 1 gene.

Journal of inherited metabolic disease

Pérez B,Medrano C,Ecay MJ,Ruiz-Sala P,Martínez-Pardo M,Ugarte M,Pérez-Cerdá C

Wed May 01 00:00:00 UTC 2013

A novel congenital disorder of glycosylation type without central nervous system involvement caused by mutations in the phosphoglucomutase 1 gene.

Journal of inherited metabolic disease

Pérez B,Medrano C,Ecay MJ,Ruiz-Sala P,Martínez-Pardo M,Ugarte M,Pérez-Cerdá C

Wed May 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Glucose phosphomutase 1; Glucose phosphomutase 2; PGM 1; PGM 2; Phosphodeoxyribomutase; phosphoglucomutase 2; Phosphoglucomutase-1; Phosphoglucomutase-2; Phosphopentomutase

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Gene Aliases: 3230402E02Rik; CDG1T; GSD14; Pgm-1; PGM1; Pgm2

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UniProt ID: (Human) P36871, (Mouse) Q7TSV4

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Entrez Gene ID: (Human) 5236, (Rat) 24645, (Mouse) 66681

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Function(s)

magnesium ion binding phosphoglucomutase activity protein binding molecular_function phosphopentomutase activity isomerase activity intramolecular transferase activity, phosphotransferases metal ion binding

Process(es)

carbohydrate metabolic process glycogen biosynthetic process glucose metabolic process cellular calcium ion homeostasis response to radiation galactose catabolic process glycogen catabolic process gluconeogenesis glycolytic process organic substance metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PGM1 Polyclonal Antibody

PGM1 Antibody (15161-1-AP) in ICC/IF

Product Details

15161-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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