Proteintech

PGRMC1 Polyclonal Antibody

PGRMC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PGRMC1 Antibody (12990-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 12990-1-AP ( PGRMC1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

PGRMC1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12990-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PGRMC1 Fusion Protein Ag3643 (43-195 aa encoded by BC034238)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.54 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YKIVRGDQP AASGDSDDDE PPPLPRLKRR DFTPAELRRF DGVQDPRILM AINGKVFDVT KGRKFYGPEG PYGVFAGRDA SRGLATFCLD KEALKDEYDD LSDLTAAQQE TLSDWESQFT FKYHHVGKLL KEGEEPTVYS DEEEPKDESA RKND (43-195 aa encoded by BC034238)

Target Information

The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Olanzapine-induced nonalcoholic fatty liver disease: The effects of differential food pattern and the involvement of PGRMC1 signaling.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Zhu Z,Cao T,Chen H,Zhang B,Lin C,Cai H

Thu Jun 01 00:00:00 UTC 2023

Insight into mitochondrial dysfunction mediated by clozapine-induced inhibition of PGRMC1 in PC12 cells.

Toxicology

Wang L,Chen Q,Ma R,Zhang B,Yang P,Cao T,Jiao S,Chen H,Lin C,Cai H

Thu Jun 01 00:00:00 UTC 2023

Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo.

Military Medical Research

He Y,Dong XH,Zhu Q,Xu YL,Chen ML,Liu Z

Mon Feb 14 00:00:00 UTC 2022

Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo.

Military Medical Research

He Y,Dong XH,Zhu Q,Xu YL,Chen ML,Liu Z

Mon Feb 14 00:00:00 UTC 2022

Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo.

Military Medical Research

He Y,Dong XH,Zhu Q,Xu YL,Chen ML,Liu Z

Mon Feb 14 00:00:00 UTC 2022

Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo.

Military Medical Research

He Y,Dong XH,Zhu Q,Xu YL,Chen ML,Liu Z

Mon Feb 14 00:00:00 UTC 2022

Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.

Frontiers in endocrinology

Cao T,Chen Q,Zhang B,Wu X,Zeng C,Zhang S,Cai H

Mon Feb 14 00:00:00 UTC 2022

A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.

Frontiers in pharmacology

Cao T,Tang M,Jiang P,Zhang B,Wu X,Chen Q,Zeng C,Li N,Zhang S,Cai H

Sat Mar 27 00:00:00 UTC 2021

Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells.

PloS one

Intlekofer KA,Clements K,Woods H,Adams H,Suvorov A,Petersen SL

Fri Feb 14 00:00:00 UTC 2020

Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.

Journal of cellular physiology

Yuan XH,Yang CR,Wang XN,Zhang LL,Gao XR,Shi ZY

Mon Jan 01 00:00:00 UTC 2018

Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.

Journal of cellular physiology

Yuan XH,Yang CR,Wang XN,Zhang LL,Gao XR,Shi ZY

Mon Jan 01 00:00:00 UTC 2018

PGRMC1 localization and putative function in the nucleolus of bovine granulosa cells and oocytes.

Reproduction (Cambridge, England)

Terzaghi L,Luciano AM,Dall'Acqua PC,Modina SC,Peluso JJ,Lodde V

Thu Mar 01 00:00:00 UTC 2018

PGRMC1 localization and putative function in the nucleolus of bovine granulosa cells and oocytes.

Reproduction (Cambridge, England)

Terzaghi L,Luciano AM,Dall'Acqua PC,Modina SC,Peluso JJ,Lodde V

Thu Mar 01 00:00:00 UTC 2018

PGRMC1 localization and putative function in the nucleolus of bovine granulosa cells and oocytes.

Reproduction (Cambridge, England)

Terzaghi L,Luciano AM,Dall'Acqua PC,Modina SC,Peluso JJ,Lodde V

Thu Mar 01 00:00:00 UTC 2018

PGRMC1 localization and putative function in the nucleolus of bovine granulosa cells and oocytes.

Reproduction (Cambridge, England)

Terzaghi L,Luciano AM,Dall'Acqua PC,Modina SC,Peluso JJ,Lodde V

Thu Mar 01 00:00:00 UTC 2018

Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.

Oncotarget

Latosinska A,Mokou M,Makridakis M,Mullen W,Zoidakis J,Lygirou V,Frantzi M,Katafigiotis I,Stravodimos K,Hupe MC,Dobrzynski M,Kolch W,Merseburger AS,Mischak H,Roubelakis MG,Vlahou A

Tue Sep 19 00:00:00 UTC 2017

PGRMC1 Elevation in Multiple Cancers and Essential Role in Stem Cell Survival.

Advances in lung cancer (Irvine)

Hampton KK,Stewart R,Napier D,Claudio PP,Craven RJ

Tue Sep 01 00:00:00 UTC 2015

A potential mechanism underlying atypical antipsychotics-induced lipid disturbances.

Translational psychiatry

Cai HL,Tan QY,Jiang P,Dang RL,Xue Y,Tang MM,Xu P,Deng Y,Li HD,Yao JK

Tue Oct 20 00:00:00 UTC 2015

A potential mechanism underlying atypical antipsychotics-induced lipid disturbances.

Translational psychiatry

Cai HL,Tan QY,Jiang P,Dang RL,Xue Y,Tang MM,Xu P,Deng Y,Li HD,Yao JK

Tue Oct 20 00:00:00 UTC 2015

The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes.

EBioMedicine

Chu UB,Mavlyutov TA,Chu ML,Yang H,Schulman A,Mesangeau C,McCurdy CR,Guo LW,Ruoho AE

Sun Nov 01 00:00:00 UTC 2015

The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes.

EBioMedicine

Chu UB,Mavlyutov TA,Chu ML,Yang H,Schulman A,Mesangeau C,McCurdy CR,Guo LW,Ruoho AE

Sun Nov 01 00:00:00 UTC 2015

Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.

Scientific reports

Zhao G,Yan G,Cheng J,Zhou X,Fang T,Sun H,Hou Y,Hu Y

Tue Jan 06 00:00:00 UTC 2015

Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.

Scientific reports

Zhao G,Yan G,Cheng J,Zhou X,Fang T,Sun H,Hou Y,Hu Y

Tue Jan 06 00:00:00 UTC 2015

Hyaluronic acid promotes the expression of progesterone receptor membrane component 1 via epigenetic silencing of miR-139-5p in human and rat granulosa cells.

Biology of reproduction

Zhao G,Zhou X,Fang T,Hou Y,Hu Y

Sat Nov 01 00:00:00 UTC 2014

Hyaluronic acid promotes the expression of progesterone receptor membrane component 1 via epigenetic silencing of miR-139-5p in human and rat granulosa cells.

Biology of reproduction

Zhao G,Zhou X,Fang T,Hou Y,Hu Y

Sat Nov 01 00:00:00 UTC 2014

Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients.

International journal of cancer

Mir SU,Ahmed IS,Arnold S,Craven RJ

Sun Jul 15 00:00:00 UTC 2012

Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients.

International journal of cancer

Mir SU,Ahmed IS,Arnold S,Craven RJ

Sun Jul 15 00:00:00 UTC 2012

Evidence for a genomic mechanism of action for progesterone receptor membrane component-1.

Steroids

Peluso JJ,DeCerbo J,Lodde V

Wed Aug 01 00:00:00 UTC 2012

Evidence for a genomic mechanism of action for progesterone receptor membrane component-1.

Steroids

Peluso JJ,DeCerbo J,Lodde V

Wed Aug 01 00:00:00 UTC 2012

Scientific Program Schedule 57th Annual Scientific Meeting.

Reproductive sciences (Thousand Oaks, Calif.)

No authors listed

Mon Mar 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: 25-DX; Acidic 25 kDa protein; Dap1; HGNC:16090; IZA; Membrane-associated progesterone receptor component 1; membrane-bound progesterone receptor; mPR; progesterone binding protein; VEMA; Ventral midline antigen

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Gene Aliases: 25-Dx; 25Dx; AA415812; HPR6.6; Lewi; MPR; PGRMC; PGRMC1; PPMR; VEMA

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UniProt ID: (Human) O00264, (Rat) P70580, (Mouse) O55022

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Entrez Gene ID: (Human) 10857, (Rat) 291948, (Mouse) 53328

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Function(s)

steroid binding protein binding heme binding lipid binding

Process(es)

axon guidance

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PGRMC1 Polyclonal Antibody

PGRMC1 Antibody (12990-1-AP) in IHC (P)

Product Details

12990-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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