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Abnova
PGRMC2 Monoclonal Antibody (2A3)
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Product Details
H00010424-M03
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2A3
Immunogen
PGRMC2 (NP_006311, 124 a.a. approximately 223 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: NGKVFDVTKG SKFYGPAGPY GIFAGRDASR GLATFCLDKD ALRDEYDDLS DLNAVQMESV REWEMQFKEK YDYVGRLLKP GEEPSEYTDE EDTKDHNKQD
Target Information
PGRMC2 (progesterone receptor membrane component 2), also known as DG6 (steroid receptor protein DG6) or PMBP (progesterone membrane-binding protein), is a single pass membrane protein belonging to the cytochrome b5 family (MAPR (membrane associated progesterone receptor) subfamily). Expressed in sperm, PGRMC2 is believed to function as a steroid receptor and may participate in the progesterone-dependent sperm acrosome reaction. PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1. The loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, implicating a potential role of PGRMC2 in the suppression of metastasis of endocervical adenocarcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Membrane-associated progesterone receptor component 2; progesterone membrane binding protein; Progesterone membrane-binding protein; Steroid receptor protein DG6
Gene Aliases: 4631434O19Rik; 5730409G06Rik; DG6; PGRMC2; PMBP
UniProt ID: (Human) O15173, (Mouse) Q80UU9, (Rat) Q5XIU9
Entrez Gene ID: (Human) 10424, (Mouse) 70804, (Rat) 361940
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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