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PHACTR1 plays a role in cell motility and in the formation of tubules by endothelial cells. PHACTR1 also binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Further, PHACTR1 regulates PPP1CA activity and is required for normal cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC126575; MGC126577; Phosphatase and actin regulator 1; RPEL repeat containing 1
Gene Aliases: 9630030F18Rik; dJ257A7.2; KIAA1733; PHACTR1; RPEL; RPEL1
UniProt ID: (Human) Q9C0D0, (Rat) P62024, (Mouse) Q2M3X8
Entrez Gene ID: (Human) 221692, (Rat) 306844, (Mouse) 218194
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