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Product Details
16481-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PHAX Fusion Protein Ag9602 (1-394 aa encoded by BC021161)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MALEVGDME DGQLSDSDSD MTVAPSDRPL QLPKVLGGDS AMRAFQNTAT ACAPVSHYRA VESVDSSEES FSDSDDDSCL WKRKRQKCFN PPPKPEPFQF GQSSQKPPVA GGKKINNIWG AVLQEQNQDA VATELGILGM EGTIDRSRQS ETYNYLLAKK LRKESQEHTK DLDKELDEYM HGGKKMGSKE EENGQGHLKR KRPVKDRLGN RPEMNYKGRY EITAEDSQEK VADEISFRLQ EPKKDLIARV VRIIGNKKAI ELLMETAEVE QNGGLFIMNG SRRRTPGGVF LNLLKNTPSI SEEQIKDIFY IENQKEYENK KAARKRRTQV LGKKMKQAIK SLNFQEDDDT SRETFASDTN EALASLDESQ EGHAEAKLEA EEAIEVDHSH DLDIF (1-394 aa encoded by BC021161)
Target Information
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26 kDa resiniferatoxin-binding protein; cytosolic resiniferatoxin-binding protein; Phosphorylated adapter RNA export protein; phosphorylation regulated; RBP-2; RBP-26; Resiniferatoxin-binding protein 2; RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adapter (phosphorylation regulated); RNA U, small nuclear RNA export adaptor; RNA U, small nuclear RNA export adaptor (phosphorylation regulated); RTX-42
Gene Aliases: 2810055C14Rik; 4933427L19Rik; AU018701; AU018854; D18Ertd65e; p55; PHAX; RNUXA
UniProt ID: (Human) Q9H814, (Rat) Q63068, (Mouse) Q9JJT9
Entrez Gene ID: (Human) 51808, (Rat) 286917, (Mouse) 56698
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