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Product Details
H00001911-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PHC1 (AAH73964.1, 1 a.a. approximately 957 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: METESEQNSN STNGSSSSGG SSRPQIAQMS LYERQAVQAT IAASRQASSP NTSTTQQQTT TTQASINLAT TSAAQLISRS QSVSSPSATT LTQSVLLGNT TSPPLNQSQA QMYLRVNRTL GRNVPLASQL ILMPNGAVAA VQQEVPSAQS PGVHADADQV QNLAVRNQQA SAQGPQMQGS TQKAIPPGAS PVSSLSQASS QALAVAQASS GATNQSLNLS QAGGGSGNSI PGSMGPGGGG QAHGGLGQLP SSGMGGGSCP RKGTGVVQPL PAAQTVTVSQ GSQTEAESAA AKKAEADGSG QQNVGMNLTR TATPAPSQTL ISSATYTQIQ PHSLIQQQQQ IHLQQKQVVI QQQIAIHHQQ QFQHRQSQLL HTATHLQLAQ QQQQQQQQQQ QQPQATTLTA PQPPQVPPTQ QVPPSQSQQQ AQTLVVQPML QSSPLSLPPD AAPKPPIPIQ SKPPVAPIKP PQLGAAKMSA AQQPPPHIPV QVVGTRQPGT AQAQALGLAQ LAAAVPTSRG MPGTVQSGQA HLASSPPSSQ APGALQECPP TLAPGMTLAP VQGTAHVVKG GATTSSPVVA QVPAAFYMQS VHLPGKPQTL AVKRKADSEE ERDDVSTLGS MLPAKASPVA ESPKVMDEKS SLGEKAESVA NVNANTPSSE LVALTPAPSV PPPTLAMVSR QMGDSKPPQA IVKPQILTHI IEGFVIQEGA EPFPVGCSQL LKESEKPLQT GLPTGLTENQ SGGSLGVDSP SAELDKKANL LKCEYCGKYA PAEQFRGSKR FCSMTCAKRY NVSCSHQFRL KRKKMKEFQE ANYARVRRRG PRRSSSDIAR AKIQGKCHRG QEDSSRGSDN SSYDEALSPT SPGPLSVRAG HGERDLGNPN TAPPTPELHG INPVFLSSNP SRWSVEEVYE FIASLQGCQE IAEEFRSQEI DGQALLLLKE EHLMSAMNIK LGPALKICAK INVLKET
Target Information
Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC1 (polyhomeotic homolog 1), also known as EDR1, HPH1 or RAE28, is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686A1782; early development regulator 1 (homolog of polyhomeotic 1); Early development regulatory protein 1; hPH1; polyhomeotic-like 1; Polyhomeotic-like protein 1
Gene Aliases: EDR1; HPH1; MCPH11; PH1; PHC1; RAE28
UniProt ID: (Human) P78364
Entrez Gene ID: (Human) 1911
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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