Proteintech

PHGDH Polyclonal Antibody

PHGDH Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

PHGDH Antibody (14719-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HepG2 cells using 14719-1-AP (PHGDH antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

PHGDH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PHGDH Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14719-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 36 publications 36 publications

Immunohistochemistry (IHC)

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PHGDH Fusion Protein Ag6445 (185-533 aa encoded by BC000303)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SFGVQQLPL EEIWPLCDFI TVHTPLLPST TGLLNDNTFA QCKKGVRVVN CARGGIVDEG ALLRALQSGQ CAGAALDVFT EEPPRDRALV DHENVISCPH LGASTKEAQS RCGEEIAVQF VDMVKGKSLT GVVNAQALTS AFSPHTKPWI GLAEALGTLM RAWAGSPKGT IQVITQGTSL KNAGNCLSPA VIVGLLKEAS KQADVNLVNA KLLVKEAGLN VTTSHSPAAP GEQGFGECLL AVALAGAPYQ AVGLVQGTTP VLQGLNGAVF RPEVPLRRDL PLLLFRTQTS DPAMLPTMIG LLAEAGVRLL SYQTSLVSDG ETWHVMGISS LLPSLEAWKQ HVTEAFQFHF (185-533 aa encoded by BC000303)

Target Information

PHGDH gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.

Cancer medicine

Zhai L,Yang X,Cheng Y,Wang J

Tue Aug 01 00:00:00 UTC 2023

Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.

Cancer medicine

Zhai L,Yang X,Cheng Y,Wang J

Tue Aug 01 00:00:00 UTC 2023

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.

Nature communications

Wu Y,Tang L,Huang H,Yu Q,Hu B,Wang G,Ge F,Yin T,Li S,Yu X

Fri Mar 10 00:00:00 UTC 2023

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.

Nature communications

Wu Y,Tang L,Huang H,Yu Q,Hu B,Wang G,Ge F,Yin T,Li S,Yu X

Fri Mar 10 00:00:00 UTC 2023

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.

Nature communications

Wu Y,Tang L,Huang H,Yu Q,Hu B,Wang G,Ge F,Yin T,Li S,Yu X

Fri Mar 10 00:00:00 UTC 2023

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.

Nature communications

Wu Y,Tang L,Huang H,Yu Q,Hu B,Wang G,Ge F,Yin T,Li S,Yu X

Fri Mar 10 00:00:00 UTC 2023

Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus Replication.

Journal of virology

Tang N,Chen P,Zhao C,Liu P,Tan L,Song C,Qiu X,Liao Y,Liu X,Luo T,Sun Y,Ding C

Thu Mar 30 00:00:00 UTC 2023

Single-cell transcriptome analyses reveal critical roles of RNA splicing during leukemia progression.

PLoS biology

Wu B,Chen X,Pan X,Deng X,Li S,Wang Z,Wang J,Liao D,Xu J,Chen M,Zhao C,Xue Z,Wang Y,Niu T,Lin J,Chen L,Liu Y,Chen C

Mon May 01 00:00:00 UTC 2023

Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.

Frontiers in oncology

Zhang Y,Gong R,Liu Y,Sun X,Liang J,Zhou Y,Wang Y,Yu W,Wang Y,Tang L,He A,Shen Z,Yao Y,Hu H,Liu X,Zhang J

Wed Feb 23 00:00:00 UTC 2022

TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine.

Experimental cell research

Luo X,Ge J,Liu J,Liu Z,Bi C,Lan S

Fri Jul 01 00:00:00 UTC 2022

Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis.

Clinical proteomics

Chen H,Lai X,Zhu Y,Huang H,Zeng L,Zhang L

Mon Nov 21 00:00:00 UTC 2022

PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.

Cell metabolism

Chen X,Calandrelli R,Girardini J,Yan Z,Tan Z,Xu X,Hiniker A,Zhong S

Tue May 03 00:00:00 UTC 2022

Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver.

Nature communications

Chen H,Liu C,Wang Q,Xiong M,Zeng X,Yang D,Xie Y,Su H,Zhang Y,Huang Y,Chen Y,Yue J,Liu C,Wang S,Huang K,Zheng L

Mon Jul 04 00:00:00 UTC 2022

PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.

Oxidative medicine and cellular longevity

Zhang X,Sun M,Jiao Y,Lin B,Yang Q

Thu Nov 16 00:00:00 UTC 2023

PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.

Oxidative medicine and cellular longevity

Zhang X,Sun M,Jiao Y,Lin B,Yang Q

Thu Nov 16 00:00:00 UTC 2023

PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.

Oxidative medicine and cellular longevity

Zhang X,Sun M,Jiao Y,Lin B,Yang Q

Thu Nov 16 00:00:00 UTC 2023

PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.

Oxidative medicine and cellular longevity

Zhang X,Sun M,Jiao Y,Lin B,Yang Q

Thu Nov 16 00:00:00 UTC 2023

PERK is a critical metabolic hub for immunosuppressive function in macrophages.

Nature immunology

Raines LN,Zhao H,Wang Y,Chen HY,Gallart-Ayala H,Hsueh PC,Cao W,Koh Y,Alamonte-Loya A,Liu PS,Ivanisevic J,Lio CJ,Ho PC,Huang SC

Tue Mar 01 00:00:00 UTC 2022

The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA.

Journal of hematology & oncology

Feng Z,Li K,Qin K,Liang J,Shi M,Ma Y,Zhao S,Liang H,Han D,Shen B,Peng C,Chen H,Jiang L

Wed Aug 17 00:00:00 UTC 2022

The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA.

Journal of hematology & oncology

Feng Z,Li K,Qin K,Liang J,Shi M,Ma Y,Zhao S,Liang H,Han D,Shen B,Peng C,Chen H,Jiang L

Wed Aug 17 00:00:00 UTC 2022

ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.

Acta pharmacologica Sinica

Li S,Yang H,Li W,Liu JY,Ren LW,Yang YH,Ge BB,Zhang YZ,Fu WQ,Zheng XJ,Du GH,Wang JH

Sat Oct 01 00:00:00 UTC 2022

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.

Nature communications

Soflaee MH,Kesavan R,Sahu U,Tasdogan A,Villa E,Djabari Z,Cai F,Tran DH,Vu HS,Ali ES,Rion H,O'Hara BP,Kelekar S,Hallett JH,Martin M,Mathews TP,Gao P,Asara JM,Manning BD,Ben-Sahra I,Hoxhaj G

Mon May 16 00:00:00 UTC 2022

Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.

The EMBO journal

Shu Y,Hao Y,Feng J,Liu H,Li ST,Feng J,Jiang Z,Ye L,Zhou Y,Sun Y,Zhou Z,Wei H,Gao P,Zhang H,Sun L

Thu Dec 01 00:00:00 UTC 2022

Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.

The Journal of clinical investigation

Zhang Y,Yu H,Zhang J,Gao H,Wang S,Li S,Wei P,Liang J,Yu G,Wang X,Li X,Li D,Yang W

Mon Nov 01 00:00:00 UTC 2021

Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.

The Journal of clinical investigation

Zhang Y,Yu H,Zhang J,Gao H,Wang S,Li S,Wei P,Liang J,Yu G,Wang X,Li X,Li D,Yang W

Mon Nov 01 00:00:00 UTC 2021

Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.

Journal of extracellular vesicles

Gao X,Wang Y,Lu F,Chen X,Yang D,Cao Y,Zhang W,Chen J,Zheng L,Wang G,Fu M,Ma L,Song Y,Zhan Q

Mon Mar 01 00:00:00 UTC 2021

Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.

Molecular medicine reports

Huang H,Liu K,Ou H,Qian X,Wan J

Tue Jun 01 00:00:00 UTC 2021

Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.

Molecular medicine reports

Huang H,Liu K,Ou H,Qian X,Wan J

Tue Jun 01 00:00:00 UTC 2021

Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors.

Cellular and molecular life sciences : CMLS

Tan Y,Zhou X,Gong Y,Gou K,Luo Y,Jia D,Dai L,Zhao Y,Sun Q

Fri Dec 31 00:00:00 UTC 2021

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.

Frontiers in cell and developmental biology

Sun S,Li C,Cui K,Liu B,Zhou M,Cao Y,Zhang J,Bian Z,Fei B,Huang Z

Tue Dec 28 00:00:00 UTC 2021

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.

Frontiers in cell and developmental biology

Sun S,Li C,Cui K,Liu B,Zhou M,Cao Y,Zhang J,Bian Z,Fei B,Huang Z

Tue Dec 28 00:00:00 UTC 2021

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.

Frontiers in cell and developmental biology

Sun S,Li C,Cui K,Liu B,Zhou M,Cao Y,Zhang J,Bian Z,Fei B,Huang Z

Tue Dec 28 00:00:00 UTC 2021

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.

Frontiers in cell and developmental biology

Sun S,Li C,Cui K,Liu B,Zhou M,Cao Y,Zhang J,Bian Z,Fei B,Huang Z

Tue Dec 28 00:00:00 UTC 2021

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.

Proceedings of the National Academy of Sciences of the United States of America

Wang J,Filippakis H,Hougard T,Du H,Ye C,Liu HJ,Zhang L,Hindi K,Bagwe S,Nijmeh J,Asara JM,Shi W,El-Chemaly S,Henske EP,Lam HC

Tue Sep 28 00:00:00 UTC 2021

Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.

Journal of dental research

Yang RL,Huang HM,Han CS,Cui SJ,Zhou YK,Zhou YH

Fri Jan 01 00:00:00 UTC 2021

Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.

Journal of dental research

Yang RL,Huang HM,Han CS,Cui SJ,Zhou YK,Zhou YH

Fri Jan 01 00:00:00 UTC 2021

Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.

Molecular metabolism

Gheller BJ,Blum JE,Lim EW,Handzlik MK,Hannah Fong EH,Ko AC,Khanna S,Gheller ME,Bender EL,Alexander MS,Stover PJ,Field MS,Cosgrove BD,Metallo CM,Thalacker-Mercer AE

Fri Jan 01 00:00:00 UTC 2021

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.

Molecular cancer

Liu X,Liu Y,Liu Z,Lin C,Meng F,Xu L,Zhang X,Zhang C,Zhang P,Gong S,Wu N,Ren Z,Song J,Zhang Y

Wed Sep 08 00:00:00 UTC 2021

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.

Molecular cancer

Liu X,Liu Y,Liu Z,Lin C,Meng F,Xu L,Zhang X,Zhang C,Zhang P,Gong S,Wu N,Ren Z,Song J,Zhang Y

Wed Sep 08 00:00:00 UTC 2021

Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis.

Oncogene

Zhang G,Yang Y,Hu H,Liu K,Li B,Zhu Y,Wang Z,Wu Q,Mei Y

Thu Apr 01 00:00:00 UTC 2021

The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.

iScience

Sinha T,Naash MI,Al-Ubaidi MR

Fri Apr 24 00:00:00 UTC 2020

Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.

Bioorganic chemistry

Guo J,Gu X,Zheng M,Zhang Y,Chen L,Li H

Sat Jun 01 00:00:00 UTC 2019

The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.

Neoplasia (New York, N.Y.)

Xu L,Wang L,Zhou L,Dorfman RG,Pan Y,Tang D,Wang Y,Yin Y,Jiang C,Zou X,Wu J,Zhang M

Wed May 01 00:00:00 UTC 2019

A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.

FEBS letters

Subedi A,Muroi M,Futamura Y,Kawamura T,Aono H,Nishi M,Ryo A,Watanabe N,Osada H

Mon Apr 01 00:00:00 UTC 2019

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.

Nature communications

Jin N,Bi A,Lan X,Xu J,Wang X,Liu Y,Wang T,Tang S,Zeng H,Chen Z,Tan M,Ai J,Xie H,Zhang T,Liu D,Huang R,Song Y,Leung EL,Yao X,Ding J,Geng M,Lin SH,Huang M

Thu Jun 20 00:00:00 UTC 2019

De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.

The Journal of biological chemistry

Fan TWM,Bruntz RC,Yang Y,Song H,Chernyavskaya Y,Deng P,Zhang Y,Shah PP,Beverly LJ,Qi Z,Mahan AL,Higashi RM,Dang CV,Lane AN

Fri Sep 06 00:00:00 UTC 2019

Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.

Life science alliance

Tian S,Feng J,Cao Y,Shen S,Cai Y,Yang D,Yan R,Wang L,Zhang H,Zhong X,Gao P

Tue Oct 01 00:00:00 UTC 2019

Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.

OncoTargets and therapy

Zhang P,Wang Q,Lin Z,Yang P,Dou K,Zhang R

Tue Apr 12 00:00:00 UTC 2022

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology

Hamanaka RB,Nigdelioglu R,Meliton AY,Tian Y,Witt LJ,O'Leary E,Sun KA,Woods PS,Wu D,Ansbro B,Ard S,Rohde JM,Dulin NO,Guzy RD,Mutlu GM

Tue May 01 00:00:00 UTC 2018

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology

Hamanaka RB,Nigdelioglu R,Meliton AY,Tian Y,Witt LJ,O'Leary E,Sun KA,Woods PS,Wu D,Ansbro B,Ard S,Rohde JM,Dulin NO,Guzy RD,Mutlu GM

Tue May 01 00:00:00 UTC 2018

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology

Hamanaka RB,Nigdelioglu R,Meliton AY,Tian Y,Witt LJ,O'Leary E,Sun KA,Woods PS,Wu D,Ansbro B,Ard S,Rohde JM,Dulin NO,Guzy RD,Mutlu GM

Tue May 01 00:00:00 UTC 2018

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology

Hamanaka RB,Nigdelioglu R,Meliton AY,Tian Y,Witt LJ,O'Leary E,Sun KA,Woods PS,Wu D,Ansbro B,Ard S,Rohde JM,Dulin NO,Guzy RD,Mutlu GM

Tue May 01 00:00:00 UTC 2018

Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling.

Scientific reports

Coleman V,Sa-Nguanmoo P,Koenig J,Schulz TJ,Grune T,Klaus S,Kipp AP,Ost M

Mon Feb 05 00:00:00 UTC 2018

Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling.

Scientific reports

Coleman V,Sa-Nguanmoo P,Koenig J,Schulz TJ,Grune T,Klaus S,Kipp AP,Ost M

Mon Feb 05 00:00:00 UTC 2018

Proximal tubule glutamine synthetase expression is necessary for the normal response to dietary protein restriction.

American journal of physiology. Renal physiology

Lee HW,Osis G,Handlogten ME,Verlander JW,Weiner ID

Sat Jul 01 00:00:00 UTC 2017

Proximal tubule glutamine synthetase expression is necessary for the normal response to dietary protein restriction.

American journal of physiology. Renal physiology

Lee HW,Osis G,Handlogten ME,Verlander JW,Weiner ID

Sat Jul 01 00:00:00 UTC 2017

Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.

Hepatology (Baltimore, Md.)

Liu S,Sun Y,Jiang M,Li Y,Tian Y,Xue W,Ding N,Sun Y,Cheng C,Li J,Miao X,Liu X,Zheng L,Huang K

Tue Aug 01 00:00:00 UTC 2017

Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.

Hepatology (Baltimore, Md.)

Liu S,Sun Y,Jiang M,Li Y,Tian Y,Xue W,Ding N,Sun Y,Cheng C,Li J,Miao X,Liu X,Zheng L,Huang K

Tue Aug 01 00:00:00 UTC 2017

Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.

Hepatology (Baltimore, Md.)

Liu S,Sun Y,Jiang M,Li Y,Tian Y,Xue W,Ding N,Sun Y,Cheng C,Li J,Miao X,Liu X,Zheng L,Huang K

Tue Aug 01 00:00:00 UTC 2017

Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.

Hepatology (Baltimore, Md.)

Liu S,Sun Y,Jiang M,Li Y,Tian Y,Xue W,Ding N,Sun Y,Cheng C,Li J,Miao X,Liu X,Zheng L,Huang K

Tue Aug 01 00:00:00 UTC 2017

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action.

Molecular metabolism

Ost M,Coleman V,Voigt A,van Schothorst EM,Keipert S,van der Stelt I,Ringel S,Graja A,Ambrosi T,Kipp AP,Jastroch M,Schulz TJ,Keijer J,Klaus S

Mon Feb 01 00:00:00 UTC 2016

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action.

Molecular metabolism

Ost M,Coleman V,Voigt A,van Schothorst EM,Keipert S,van der Stelt I,Ringel S,Graja A,Ambrosi T,Kipp AP,Jastroch M,Schulz TJ,Keijer J,Klaus S

Mon Feb 01 00:00:00 UTC 2016

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

The Journal of biological chemistry

Nigdelioglu R,Hamanaka RB,Meliton AY,O'Leary E,Witt LJ,Cho T,Sun K,Bonham C,Wu D,Woods PS,Husain AN,Wolfgeher D,Dulin NO,Chandel NS,Mutlu GM

Fri Dec 30 00:00:00 UTC 2016

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

The Journal of biological chemistry

Nigdelioglu R,Hamanaka RB,Meliton AY,O'Leary E,Witt LJ,Cho T,Sun K,Bonham C,Wu D,Woods PS,Husain AN,Wolfgeher D,Dulin NO,Chandel NS,Mutlu GM

Fri Dec 30 00:00:00 UTC 2016

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

The Journal of biological chemistry

Nigdelioglu R,Hamanaka RB,Meliton AY,O'Leary E,Witt LJ,Cho T,Sun K,Bonham C,Wu D,Woods PS,Husain AN,Wolfgeher D,Dulin NO,Chandel NS,Mutlu GM

Fri Dec 30 00:00:00 UTC 2016

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

The Journal of biological chemistry

Nigdelioglu R,Hamanaka RB,Meliton AY,O'Leary E,Witt LJ,Cho T,Sun K,Bonham C,Wu D,Woods PS,Husain AN,Wolfgeher D,Dulin NO,Chandel NS,Mutlu GM

Fri Dec 30 00:00:00 UTC 2016

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

Cell research

Sun L,Song L,Wan Q,Wu G,Li X,Wang Y,Wang J,Liu Z,Zhong X,He X,Shen S,Pan X,Li A,Wang Y,Gao P,Tang H,Zhang H

Wed Apr 01 00:00:00 UTC 2015

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

Cell research

Sun L,Song L,Wan Q,Wu G,Li X,Wang Y,Wang J,Liu Z,Zhong X,He X,Shen S,Pan X,Li A,Wang Y,Gao P,Tang H,Zhang H

Wed Apr 01 00:00:00 UTC 2015

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ost M,Keipert S,van Schothorst EM,Donner V,van der Stelt I,Kipp AP,Petzke KJ,Jove M,Pamplona R,Portero-Otin M,Keijer J,Klaus S

Wed Apr 01 00:00:00 UTC 2015

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ost M,Keipert S,van Schothorst EM,Donner V,van der Stelt I,Kipp AP,Petzke KJ,Jove M,Pamplona R,Portero-Otin M,Keijer J,Klaus S

Wed Apr 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: 2-oxoglutarate reductase; 3-PGDH; 3-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehyrogenase; A10; D-3-phosphoglycerate dehydrogenase; epididymis secretory protein Li 113; Malate dehydrogenase

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Gene Aliases: 3-PGDH; 3PGDH; 4930479N23; A10; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PGDH3; PHGDH; PHGDHD; SERA

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UniProt ID: (Human) O43175, (Mouse) Q61753, (Rat) O08651

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Entrez Gene ID: (Human) 26227, (Mouse) 236539, (Rat) 58835

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Function(s)

phosphoglycerate dehydrogenase activity electron carrier activity NAD binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Process(es)

glutamine metabolic process glycine metabolic process L-serine biosynthetic process threonine metabolic process brain development serine family amino acid biosynthetic process gamma-aminobutyric acid metabolic process regulation of gene expression taurine metabolic process spinal cord development glial cell development neural tube development neuron projection development oxidation-reduction process G1 to G0 transition L-serine metabolic process metabolic process cellular amino acid biosynthetic process neurogenesis

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PHGDH Polyclonal Antibody

PHGDH Antibody (14719-1-AP) in ICC/IF

Product Details

14719-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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