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Proteintech
PHIP Polyclonal Antibody
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Product Details
20933-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PHIP Fusion Protein Ag14968 (1472-1821 aa encoded by BC008909)
Conjugate
Form
Liquid
Concentration
0.82 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ESSTSAFST PTRSIPPRHN AAQINGKTES SSVVRTRSNR VVVDPVVTEQ PSTSSAAKTF ITKANASAIP GKTILENSVK HSKALNTLSS PGQSSFSHGT RNNSAKENME KEKPVKRKMK SSVLPKASTL SKSSAVIEQG DCKNNALVPG TIQVNGHGGQ PSKLVKRGPG RKPKVEVNTN SGEIIHKKRG RKPKKLQYAK PEDLEQNNVH PIRDEVLPSS TCNFLSETNN VKEDLLQKKN RGGRKPKRKM KTQKLDADLL VPASVKVLRR SNRKKIDDPI DEEEEFEELK GSEPHMRTRN QGRRTAFYNE DDSEEEQRQL LFEDTSLTFG TSSRGRVRKL TEKAKANLIG W (1472-1821 aa encoded by BC008909)
Target Information
PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing beta cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DDB1 and CUL4 associated factor 14; DDB1- and CUL4-associated factor 14; FLJ20705; IRS-1 PH domain-binding protein; neuronal differentiation related protein; neuronal differentiation-related protein; PH-interacting protein; PHIP; WD repeat domain 11; WD repeat-containing protein 11
Gene Aliases: 2810004D21Rik; 4632404O06Rik; BRWD2; DCAF14; Ndrp; PHIP; WDR11
UniProt ID: (Human) Q8WWQ0
Entrez Gene ID: (Human) 55023, (Mouse) 83946
regulation of protein phosphorylation
regulation of transcription from RNA polymerase II promoter
protein import into nucleus
cytoskeleton organization
positive regulation of cell proliferation
insulin receptor signaling pathway
regulation of cell shape
positive regulation of peptidyl-threonine phosphorylation
regulation of cell morphogenesis
positive regulation of peptidyl-serine phosphorylation
regulation of growth
negative regulation of apoptotic process
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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