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Proteintech
PHKB Polyclonal Antibody
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Product Details
13400-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PHKB Fusion Protein Ag4240 (736-1086 aa encoded by BC033657)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LLGILLKRE GPNFITKEGT VSDHIERVYR RAGSQKLWSV VRRAASLLSK VVDSLAPSIT NVLVQGKQVT LGAFGHEEEV ISNPLSPRVI QNIIYYKCNT HDEREAVIQQ ELVIHIGWII SNNPELFSGM LKIRIGWIIH AMEYELQIRG GDKPALDLYQ LSPSEVKQLL LDILQPQQNG RCWLNRRQID GSLNRTPTGF YDRVWQILER TPNGIIVAGK HLPQQPTLSD MTMYEMNFSL LVEDTLGNID QPQYRQIVVE LLMVVSIVLE RNPELEFQDK VDLDRLVKEA FNEFQKDQSR LKEIEKQDDM TSFYNTPPLG KRGTCSYLTK AVMNLLLEGE VKPNNDDPCL IS (736-1086 aa encoded by BC033657)
Target Information
Phosphorylase kinase is a hexadecameric enzyme that is comprised of four copies of four subunits that are encoded by four separate genes: PHKA, PHKB, PHKG, and PHKD. This serine/threonine specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, resulting in the release of glucose-1-phophate from glycogen. PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093 amino acid subunit of phosphorylase kinase that, along with PHKA, has regulatory functions controlled by phosphorylation. Defects in the gene encoding PHKB are the cause of glycogen storage disease type 9B, which is also known as phosphorylase kinase deficiency of liver and muscle. This disease is characterized by a mild phenotype of hepatomegaly with only slightly elevated transaminase and plasma lipids, no clinical muscle involvement, and generally is correlated with a gradual improvement with increasing age. There are four isoforms of PHKB that are produced as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Phosphorylase B; Phosphorylase b kinase regulatory subunit beta; phosphorylase kinase; phosphorylase kinase beta subunit; phosphorylase kinase beta-subunit; Phosphorylase kinase subunit beta; phosphorylase kinase, beta
Gene Aliases: AI463271; PHKB
UniProt ID: (Human) Q93100, (Mouse) Q7TSH2
Entrez Gene ID: (Human) 5257, (Mouse) 102093
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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