Product References
A multiprotein signaling complex sustains AKT and mTOR/S6K activity necessary for the survival of cancer cells undergoing stress.
bioRxiv : the preprint server for biology
Teran Pumar OY,Zanotelli MR,Lin MJ,Schmitt RR,Green KS,Rojas KS,Hwang IY,Cerione RA,Wilson KF
Tue Oct 01 00:00:00 UTC 2024
Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.
Cardiovascular drugs and therapy
Qiu Y,Meng Y,Jia Y,Lang X,Zhao H,Ding L,Wang T,Sun H,Gao S
Fri Dec 01 00:00:00 UTC 2023
FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP.
Cell death & disease
Tufano M,Marrone L,D'Ambrosio C,Di Giacomo V,Urzini S,Xiao Y,Matuozzo M,Scaloni A,Romano MF,Romano S
Mon Feb 13 00:00:00 UTC 2023
FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP.
Cell death & disease
Tufano M,Marrone L,D'Ambrosio C,Di Giacomo V,Urzini S,Xiao Y,Matuozzo M,Scaloni A,Romano MF,Romano S
Mon Feb 13 00:00:00 UTC 2023
Low-Intensity Pulsed Ultrasound Attenuates Postoperative Neurocognitive Impairment and Salvages Hippocampal Synaptogenesis in Aged Mice.
Brain sciences
Wang Q,Liu T,Chang H,Li Z,Chen L,Mi X,Xing H,Wang X,Hong J,Liu K,Li Y,Han D,Li Y,Yang N,Li X,Li Y,Guo X
Thu Apr 13 00:00:00 UTC 2023
Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload.
Journal of pineal research
Qin X,Fu Y,Fan J,Liu B,Liu P,Zhang Y,Jiang T,Zheng Q
Sat Apr 01 00:00:00 UTC 2023
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Nature cell biology
Thomas GE,Egan G,García-Prat L,Botham A,Voisin V,Patel PS,Hoff FW,Chin J,Nachmias B,Kaufmann KB,Khan DH,Hurren R,Wang X,Gronda M,MacLean N,O'Brien C,Singh RP,Jones CL,Harding SM,Raught B,Arruda A,Minden MD,Bader GD,Hakem R,Kornblau S,Dick JE,Schimmer AD
Wed Jun 01 00:00:00 UTC 2022
PHLPP1 regulates CFTR activity and lumen expansion through AMPK.
Development (Cambridge, England)
Lobert VH,Skardal ML,Malerød L,Simensen JE,Algra HA,Andersen AN,Fleischer T,Enserink HA,Liestøl K,Heath JK,Rusten TE,Stenmark HA
Sat Oct 15 00:00:00 UTC 2022
PHLPP1 regulates CFTR activity and lumen expansion through AMPK.
Development (Cambridge, England)
Lobert VH,Skardal ML,Malerød L,Simensen JE,Algra HA,Andersen AN,Fleischer T,Enserink HA,Liestøl K,Heath JK,Rusten TE,Stenmark HA
Sat Oct 15 00:00:00 UTC 2022
Circular RNA circRASSF5 Functions as an Anti-Oncogenic Factor in Hepatocellular Carcinoma by Acting as a Competitive Endogenous RNA Through Sponging miR-331-3p.
Journal of hepatocellular carcinoma
Zhou Z,Cui X,Gao P,Zhang X,Zhu C,Sun B
Wed Oct 12 00:00:00 UTC 2022
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.
Molecular cancer
Jiang T,Wang H,Liu L,Song H,Zhang Y,Wang J,Liu L,Xu T,Fan R,Xu Y,Wang S,Shi L,Zheng L,Wang R,Song J
Sat Dec 18 00:00:00 UTC 2021
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.
Molecular cancer
Jiang T,Wang H,Liu L,Song H,Zhang Y,Wang J,Liu L,Xu T,Fan R,Xu Y,Wang S,Shi L,Zheng L,Wang R,Song J
Sat Dec 18 00:00:00 UTC 2021
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.
Molecular cancer
Jiang T,Wang H,Liu L,Song H,Zhang Y,Wang J,Liu L,Xu T,Fan R,Xu Y,Wang S,Shi L,Zheng L,Wang R,Song J
Sat Dec 18 00:00:00 UTC 2021
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.
Molecular cancer
Jiang T,Wang H,Liu L,Song H,Zhang Y,Wang J,Liu L,Xu T,Fan R,Xu Y,Wang S,Shi L,Zheng L,Wang R,Song J
Sat Dec 18 00:00:00 UTC 2021
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.
Molecular cancer
Jiang T,Wang H,Liu L,Song H,Zhang Y,Wang J,Liu L,Xu T,Fan R,Xu Y,Wang S,Shi L,Zheng L,Wang R,Song J
Sat Dec 18 00:00:00 UTC 2021
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.
Molecular cancer
Jiang T,Wang H,Liu L,Song H,Zhang Y,Wang J,Liu L,Xu T,Fan R,Xu Y,Wang S,Shi L,Zheng L,Wang R,Song J
Sat Dec 18 00:00:00 UTC 2021
Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling.
Frontiers in oncology
Wang W,Xia X,Chen K,Chen M,Meng Y,Lv D,Yang H
Sun Apr 24 00:00:00 UTC 2022
CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription.
Cellular & molecular immunology
Song Y,Li P,Qin L,Xu Z,Jiang B,Ma C,Shao C,Gong Y
Mon Feb 01 00:00:00 UTC 2021
Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity.
The Journal of biological chemistry
Troyanovsky RB,Indra I,Kato R,Mitchell BJ,Troyanovsky SM
Mon Nov 01 00:00:00 UTC 2021
The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.
Molecular and cellular biology
Kawashima AT,Wong C,Lordén G,King CC,Lara-Gonzalez P,Desai A,Gingras AC,Newton AC
Tue Feb 23 00:00:00 UTC 2021
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Cell reports
Lupse B,Annamalai K,Ibrahim H,Kaur S,Geravandi S,Sarma B,Pal A,Awal S,Joshi A,Rafizadeh S,Madduri MK,Khazaei M,Liu H,Yuan T,He W,Gorrepati KDD,Azizi Z,Qi Q,Ye K,Oberholzer J,Maedler K,Ardestani A
Tue Aug 03 00:00:00 UTC 2021
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Cell reports
Lupse B,Annamalai K,Ibrahim H,Kaur S,Geravandi S,Sarma B,Pal A,Awal S,Joshi A,Rafizadeh S,Madduri MK,Khazaei M,Liu H,Yuan T,He W,Gorrepati KDD,Azizi Z,Qi Q,Ye K,Oberholzer J,Maedler K,Ardestani A
Tue Aug 03 00:00:00 UTC 2021
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Cell reports
Lupse B,Annamalai K,Ibrahim H,Kaur S,Geravandi S,Sarma B,Pal A,Awal S,Joshi A,Rafizadeh S,Madduri MK,Khazaei M,Liu H,Yuan T,He W,Gorrepati KDD,Azizi Z,Qi Q,Ye K,Oberholzer J,Maedler K,Ardestani A
Tue Aug 03 00:00:00 UTC 2021
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Cell reports
Lupse B,Annamalai K,Ibrahim H,Kaur S,Geravandi S,Sarma B,Pal A,Awal S,Joshi A,Rafizadeh S,Madduri MK,Khazaei M,Liu H,Yuan T,He W,Gorrepati KDD,Azizi Z,Qi Q,Ye K,Oberholzer J,Maedler K,Ardestani A
Tue Aug 03 00:00:00 UTC 2021
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Cell reports
Lupse B,Annamalai K,Ibrahim H,Kaur S,Geravandi S,Sarma B,Pal A,Awal S,Joshi A,Rafizadeh S,Madduri MK,Khazaei M,Liu H,Yuan T,He W,Gorrepati KDD,Azizi Z,Qi Q,Ye K,Oberholzer J,Maedler K,Ardestani A
Tue Aug 03 00:00:00 UTC 2021
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Cell reports
Lupse B,Annamalai K,Ibrahim H,Kaur S,Geravandi S,Sarma B,Pal A,Awal S,Joshi A,Rafizadeh S,Madduri MK,Khazaei M,Liu H,Yuan T,He W,Gorrepati KDD,Azizi Z,Qi Q,Ye K,Oberholzer J,Maedler K,Ardestani A
Tue Aug 03 00:00:00 UTC 2021
Chondrocytic and pharmacokinetic properties of Phlpp inhibitors.
Osteoarthritis and cartilage open
Taylor EL,Weaver SR,Zars EL,Turner CA,Buhrow SA,Reid JM,Bradley EW,Westendorf JJ
Wed Sep 01 00:00:00 UTC 2021
Chondrocytic and pharmacokinetic properties of Phlpp inhibitors.
Osteoarthritis and cartilage open
Taylor EL,Weaver SR,Zars EL,Turner CA,Buhrow SA,Reid JM,Bradley EW,Westendorf JJ
Wed Sep 01 00:00:00 UTC 2021
Intermittent Bolus Compared With Continuous Feeding Enhances Insulin and Amino Acid Signaling to Translation Initiation in Skeletal Muscle of Neonatal Pigs.
The Journal of nutrition
Suryawan A,El-Kadi SW,Nguyen HV,Fiorotto ML,Davis TA
Sat Sep 04 00:00:00 UTC 2021
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
PLoS biology
He X,Li M,Yu H,Liu G,Wang N,Yin C,Tu Q,Narla G,Tao Y,Cheng S,Yin H
Tue Dec 01 00:00:00 UTC 2020
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
EMBO reports
Goldbraikh D,Neufeld D,Eid-Mutlak Y,Lasry I,Gilda JE,Parnis A,Cohen S
Fri Apr 03 00:00:00 UTC 2020
Cigarette smoke extract induces airway epithelial cell death via repressing PRMT6/AKT signaling.
Aging
Li T,Fanning KV,Nyunoya T,Chen Y,Zou C
Tue Dec 01 00:00:00 UTC 2020
Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3K/Akt/mTOR signalling pathway in diabetic cardiomyopathy.
Journal of cellular and molecular medicine
Zhang M,Wang X,Liu M,Liu D,Pan J,Tian J,Jin T,Xu Y,An F
Wed Apr 01 00:00:00 UTC 2020
Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3K/Akt/mTOR signalling pathway in diabetic cardiomyopathy.
Journal of cellular and molecular medicine
Zhang M,Wang X,Liu M,Liu D,Pan J,Tian J,Jin T,Xu Y,An F
Wed Apr 01 00:00:00 UTC 2020
Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3K/Akt/mTOR signalling pathway in diabetic cardiomyopathy.
Journal of cellular and molecular medicine
Zhang M,Wang X,Liu M,Liu D,Pan J,Tian J,Jin T,Xu Y,An F
Wed Apr 01 00:00:00 UTC 2020
Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.
Molecular cell
Baffi TR,Van AN,Zhao W,Mills GB,Newton AC
Thu Apr 18 00:00:00 UTC 2019
Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.
Molecular cell
Baffi TR,Van AN,Zhao W,Mills GB,Newton AC
Thu Apr 18 00:00:00 UTC 2019
Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice.
Cell death & disease
Zhang C,Smith MP,Zhou GK,Lai A,Hoy RC,Mroz V,Torre OM,Laudier DM,Bradley EW,Westendorf JJ,Iatridis JC,Illien-Jünger S
Thu Oct 03 00:00:00 UTC 2019
PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.
eLife
Cohen Katsenelson K,Stender JD,Kawashima AT,Lordén G,Uchiyama S,Nizet V,Glass CK,Newton AC
Tue Aug 13 00:00:00 UTC 2019
High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma.
Oncotarget
Xie Y,Lv D,Wang W,Ye M,Chen X,Yang H
Tue Aug 29 00:00:00 UTC 2017
High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma.
Oncotarget
Xie Y,Lv D,Wang W,Ye M,Chen X,Yang H
Tue Aug 29 00:00:00 UTC 2017
High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma.
Oncotarget
Xie Y,Lv D,Wang W,Ye M,Chen X,Yang H
Tue Aug 29 00:00:00 UTC 2017
High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma.
Oncotarget
Xie Y,Lv D,Wang W,Ye M,Chen X,Yang H
Tue Aug 29 00:00:00 UTC 2017
PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.
Cell death discovery
Xiong X,Wen YA,Mitov MI,C Oaks M,Miyamoto S,Gao T
Wed Sep 30 00:00:00 UTC 2020
PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.
Cell death discovery
Xiong X,Wen YA,Mitov MI,C Oaks M,Miyamoto S,Gao T
Wed Sep 30 00:00:00 UTC 2020
Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.
The Journal of biological chemistry
Xiong X,Li X,Wen YA,Gao T
Fri Nov 25 00:00:00 UTC 2016
Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.
The Journal of biological chemistry
Xiong X,Li X,Wen YA,Gao T
Fri Nov 25 00:00:00 UTC 2016
Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.
The Journal of biological chemistry
Xiong X,Li X,Wen YA,Gao T
Fri Nov 25 00:00:00 UTC 2016
PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells.
Oncotarget
Smith AJ,Wen YA,Stevens PD,Liu J,Wang C,Gao T
Tue Feb 16 00:00:00 UTC 2016
PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells.
Oncotarget
Smith AJ,Wen YA,Stevens PD,Liu J,Wang C,Gao T
Tue Feb 16 00:00:00 UTC 2016
Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.
Biochimica et biophysica acta
Wen YA,Li X,Goretsky T,Weiss HL,Barrett TA,Gao T
Thu Oct 01 00:00:00 UTC 2015
Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.
Biochimica et biophysica acta
Wen YA,Li X,Goretsky T,Weiss HL,Barrett TA,Gao T
Thu Oct 01 00:00:00 UTC 2015
