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Invitrogen
PHLPP1 Polyclonal Antibody
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Product Details
PA5-75679
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human PHLPP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719407
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Circadian Oscillatory Protein (SCOP); EC 3.1.3.16; hSCOP; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; Pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; protein phosphatase, Mg2+/Mn2+ dependent 3A; SCN circadian oscillatory protein; Suprachiasmatic nucleus circadian oscillatory protein
Gene Aliases: AI836256; KIAA0606; mKIAA0606; PHLPP; PHLPP1; PLEKHE1; PPM3A; SCOP
UniProt ID: (Human) O60346, (Mouse) Q8CHE4, (Rat) Q9WTR8
Entrez Gene ID: (Human) 23239, (Mouse) 98432, (Rat) 59265
regulation of protein phosphorylation
protein dephosphorylation
apoptotic process
entrainment of circadian clock
negative regulation of protein kinase B signaling
negative regulation of protein kinase C signaling
circadian rhythm
metabolic process
hippocampus development
regulation of T cell anergy
regulation of apoptotic process
regulation of MAPK cascade
regulation of JNK cascade
regulation of p38MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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