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Bioss
PHOX2A/CFEOM2 Polyclonal Antibody
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Product Details
BS-11577R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PHOX2A, amino acids 41-140.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aristaless homeobox gene homolog; aristaless homeobox homolog; Aristaless homeobox protein homolog; arix homeodomain protein; ARIX1 homeodomain protein; paired mesoderm homeobox 2a; Paired mesoderm homeobox protein 2A; Paired-like homeobox 2A; PHOX2A homeodomain protein
Gene Aliases: ARIX; CFEOM2; FEOM2; NCAM2; Phox2; PHOX2A; Pmx2; PMX2A
UniProt ID: (Human) O14813, (Mouse) Q62066, (Rat) Q62782
Entrez Gene ID: (Human) 401, (Mouse) 11859, (Rat) 116648
noradrenergic neuron differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
somatic motor neuron differentiation
oculomotor nerve formation
trochlear nerve formation
locus ceruleus development
midbrain development
regulation of respiratory gaseous exchange
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
parasympathetic nervous system development
aging
dopaminergic neuron differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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