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The protein encoded by this gene is a member of the serine protease inhibitor superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.
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Protein Aliases: Myoepithelium-derived serine protease inhibitor; neuroserpin; Pancpin; Pancreas-specific protein TSA2004; pancreas-specific serpin; Peptidase inhibitor 14; PI-14; protease inhibitor 14; serine (or cysteine) peptidase inhibitor, clade I, member 2; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2; serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2; Serine protease inhibitor 14; Serpin I2; serpin peptidase inhibitor, clade I (pancpin), member 2; serpin peptidase inhibitor, clade I, member 2; SERPIN12
Gene Aliases: MEPI; PANCPIN; PI14; SERPINI2; Spi14; TSA2004
UniProt ID: (Human) O75830, (Mouse) Q9JK88
Entrez Gene ID: (Human) 5276, (Rat) 171149, (Mouse) 67931
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