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PI3 Kinase p110 Beta Monoclonal Antibody (1B2A1)

PI3 Kinase p110 Beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PI3 Kinase p110 Beta Antibody (67121-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 67121-1-Ig (PIK3CB antibody) at dilution of 1:300 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

PI3 Kinase p110 Beta Antibody in Western Blot (WB)

Product Image Gallery

Product Details

67121-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:300

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1B2A1

Immunogen

PIK3CB Fusion Protein Ag17505

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

860 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

PIK3CB (phosphatyidylinositol 4,5-biphosphate 3-kinase catalyic subunit beta isoform) is a phosphoinositide-3-kinase that phosphorylates PtdIns (phosphatidylinositol), PtdIns4P (phosphatidylinositol 4-phosphate), and PtdIns(4,5)P2 (phosphatidylinositol 4,5-biphosphate) to generate phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 plays a key role in recruiting PH domain-containing proteins to the membrane and activating signaling cascades involved in cell growth, survival, proliferation, motility, and morphology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.

Chinese journal of integrative medicine

Ge XF,Li SS,Liu YH,Lu MQ,Su HN,Yang X,Sun XW

Thu Jun 01 00:00:00 UTC 2023

PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model.

Experimental and therapeutic medicine

Zhang P,Jiang Y,Ye X,Zhang C,Tang Y

Mon May 01 00:00:00 UTC 2023

Promotion of the genipin crosslinked chitosan-fiber hydrogel loaded with sustained release of clemastine fumarate in diabetic wound repair.

International journal of biological macromolecules

Zuo R,Shi J,Jiang S,Chu M,Wang Q,Kong L,Kang Q,Guo Y,Guan J

Tue Jan 31 00:00:00 UTC 2023

Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.

Biological trace element research

Fang Z,Li Y,Wang J,Wang X,Huang L,Sun L,Deng Q

Fri Sep 01 00:00:00 UTC 2023

Antitumor mechanism of kangliu pill on gliomas in mice through PI3K-Akt signaling pathway.

Journal of ethnopharmacology

Chen F,Cui JJ,Jiang DC,Wang HZ,Zhuang W,Feng YN,Lin XL,Xi SY

Wed May 10 00:00:00 UTC 2023

Effects of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione on autophagy and the PI3K/AKT/mTOR signaling pathway in human cholangiocarcinoma QBC939 cells.

Journal of gastrointestinal oncology

He Y,Li Y,Liang T,Mo S,Liao Y,Chen Z,Zhao S,Ran Q,Han C,Hoa PTT

Wed Jun 01 00:00:00 UTC 2022

Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.

Evidence-based complementary and alternative medicine : eCAM

Wu YY,Huang YL,Dai B,Liu JW,Han X

Sat Jul 16 00:00:00 UTC 2022

Extracellular Vesicles from BMSCs Prevent Glucocorticoid-Induced BMECs Injury by Regulating Autophagy via the PI3K/Akt/mTOR Pathway.

Cells

Ma J,Shen M,Yue D,Wang W,Gao F,Wang B

Sun Jul 03 00:00:00 UTC 2022

l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.

Journal of biochemical and molecular toxicology

Liang M,Wang Z,Li H,Liu B,Yang L

Mon Aug 01 00:00:00 UTC 2022

Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene.

Frontiers in oncology

Zhang J,Tang Z,Guo X,Wang Y,Zhou Y,Cai W

Wed Nov 29 00:00:00 UTC 2023

circRNF10 Regulates Tumorigenic Properties and Natural Killer Cell-Mediated Cytotoxicity against Breast Cancer through the miR-934/PTEN/PI3k-Akt Axis.

Cancers

Liu F,Sang Y,Zheng Y,Gu L,Meng L,Li Z,Dong Y,Wei Z,Geng C,Sang M

Mon Nov 28 00:00:00 UTC 2022

Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.

Chinese medicine

Xu H,Xu S,Li L,Wu Y,Mai S,Xie Y,Tan Y,Li A,Xue F,He X,Li Y

Thu Nov 24 00:00:00 UTC 2022

The expression and prognostic significance of PIK3CB in lung adenocarcinoma.

Annals of diagnostic pathology

Che N,Zhao N,Zhao X,Su S,Zhang Y,Bai X,Li F,Zhang D,Li Y

Sat Oct 01 00:00:00 UTC 2022

LncRNA LINC00460 facilitates the proliferation and metastasis of renal cell carcinoma via PI3K/AKT signaling pathway.

Journal of Cancer

Zhou FJ,Meng S,Wu XF,Hou PF,Li ML,Chu SF,Bai J,Zheng JN

Tue Aug 02 00:00:00 UTC 2022

Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.

Journal of medicinal chemistry

Hou Y,Zhang F,Min W,Yuan K,Kuang W,Wang X,Zhu Y,Sun C,Xia F,Wang Y,Zhang H,Wang L,Yang P

Thu Jul 28 00:00:00 UTC 2022

Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.

Bioorganic chemistry

Ma Y,Yang X,Han H,Wen Z,Yang M,Zhang Y,Fu J,Wang X,Yin T,Lu G,Qi J,Lin H,Wang X,Yang Y

Tue Jun 01 00:00:00 UTC 2021

Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.

Evidence-based complementary and alternative medicine : eCAM

Yang R,Wen J,Yang T,Dai C,Zhao Y

Thu Apr 28 00:00:00 UTC 2022

Relationship Between PTEN and Angiogenesis of Esophageal Squamous Cell Carcinoma and the Underlying Mechanism.

Frontiers in oncology

Yang C,Chen C,Xiao Q,Wang X,Shou Y,Tian X,Wang S,Li H,Liang Y,Shu J,Chen K,Sun M

Sat Nov 20 00:00:00 UTC 2021

Relationship Between PTEN and Angiogenesis of Esophageal Squamous Cell Carcinoma and the Underlying Mechanism.

Frontiers in oncology

Yang C,Chen C,Xiao Q,Wang X,Shou Y,Tian X,Wang S,Li H,Liang Y,Shu J,Chen K,Sun M

Sat Nov 20 00:00:00 UTC 2021

Paeoniflorin-6'-O-benzene sulfonate down-regulates CXCR4-Gβγ-PI3K/AKT mediated migration in fibroblast-like synoviocytes of rheumatoid arthritis by inhibiting GRK2 translocation.

Biochemical and biophysical research communications

Wang DD,Jiang MY,Wang W,Zhou WJ,Zhang YW,Yang M,Chen JY,Wei W

Thu Jun 04 00:00:00 UTC 2020

Paeoniflorin-6'-O-benzene sulfonate down-regulates CXCR4-Gβγ-PI3K/AKT mediated migration in fibroblast-like synoviocytes of rheumatoid arthritis by inhibiting GRK2 translocation.

Biochemical and biophysical research communications

Wang DD,Jiang MY,Wang W,Zhou WJ,Zhang YW,Yang M,Chen JY,Wei W

Thu Jun 04 00:00:00 UTC 2020

Apigenin ameliorates vascular injury in rats with high fructose-induced metabolic disturbance by inhibiting PI3K/AKT/GLUT1.

RSC advances

Chen X,Tan J,Zhang L,Liu Y,Cheng Y,Zhang Q,Ding H

Mon Jul 02 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: catalytic phosphatidylinositol 3-kinase beta; p110beta; phosphatidylinositol 3-kinase catalytic subunit beta isoform; phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3Kbeta; pi3kcb; PtdIns-3-kinase p110; ptdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB

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Gene Aliases: P110BETA; PI3K; PI3KBETA; PIK3C1; PIK3CB

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UniProt ID: (Human) P42338, (Rat) Q9Z1L0

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Entrez Gene ID: (Human) 5291, (Rat) 85243

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Function(s)

protein binding ATP binding 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Process(es)

activation of MAPK activity endothelial cell proliferation regulation of cell-matrix adhesion phosphatidylinositol biosynthetic process cellular calcium ion homeostasis autophagy chemotaxis homophilic cell adhesion via plasma membrane adhesion molecules signal transduction transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway positive regulation of autophagy positive regulation of gene expression phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling cell migration platelet activation phosphatidylinositol-3-phosphate biosynthetic process Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis embryonic cleavage phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway phosphatidylinositol-mediated signaling T cell receptor signaling pathway leukocyte migration angiogenesis involved in wound healing platelet aggregation regulation of clathrin-mediated endocytosis endocytosis cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PI3 Kinase p110 Beta Monoclonal Antibody (1B2A1)

PI3 Kinase p110 Beta Antibody (67121-1-IG) in IHC (P)

Product Details

67121-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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