Invitrogen

PIAS1 Recombinant Rabbit Monoclonal Antibody (JE36-84)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-44844

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Flow Cytometry (Flow)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JE36-84

Immunogen

Synthetic peptide within human PIAS1 aa 71-120/651.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931300

Target Information

PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AR interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; GBP; Gu binding protein; Gu-binding protein; Protein inhibitor of activated STAT protein 1; protein inhibitor of activated STAT-1; RING-type E3 ubiquitin transferase PIAS1; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3

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Gene Aliases: 2900068C24Rik; DDXBP1; GBP; GU/RH-II; PIAS1; ZMIZ3

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UniProt ID: (Human) O75925, (Mouse) O88907

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Entrez Gene ID: (Human) 8554, (Mouse) 56469

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Function(s)
DNA binding transcription coactivator activity transcription corepressor activity protein binding transcription factor binding zinc ion binding ligase activity SUMO transferase activity enzyme binding ubiquitin protein ligase binding androgen receptor binding SUMO ligase activity protein C-terminus binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity protein domain specific binding coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated JAK-STAT cascade protein sumoylation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein sumoylation regulation of cell proliferation negative regulation of apoptotic process fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of smooth muscle cell differentiation protein-DNA complex assembly negative regulation of nucleic acid-templated transcription androgen receptor signaling pathway regulation of interferon-gamma-mediated signaling pathway
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