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Product Details
PA5-52288
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PIAS3. Recombinant protein control fragment (Product #RP-104011).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645534
Product Specific Information
Immunogen sequence: PTKKHCSVTS AAIPALPGSK GVLTSGHQPS SVLRSPAMGT LGGDFLSSLP LHEYPPAFPL GADIQGLDLF SFLQTESQHY GPSVITSLDE QDALGHFFQY RGTPSHFLGP LAPTLGSSHC SATPAPPPGR VSSIVAPG
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 93%.
Target Information
The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; Protein inhibitor of activated STAT protein 3; protein inhibitor of activated STAT, 3; zinc finger, MIZ-type containing 5
Gene Aliases: PIAS3; ZMIZ5
UniProt ID: (Human) Q9Y6X2
Entrez Gene ID: (Human) 10401
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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