Invitrogen

PIK3CA Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-99395

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PIK3CA(Accession P42336), corresponding to amino acid residues S499-D549.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818328

Product Specific Information

Antibody detects endogenous levels of total PI3 kinase P110 alpha.

Target Information

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K alpha; PI3K-alpha; PI3Kalpha; pi3kca; PIK3R1; pk3ca; ptdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA

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Gene Aliases: 6330412C24Rik; caPI3K; CLOVE; CWS5; MCAP; MCM; MCMTC; p110; p110-alpha; p110alpha; PI3K; PI3K-alpha; PIK3CA

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UniProt ID: (Human) P42336, (Mouse) P42337, (Rat) A0A0G2K344

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Entrez Gene ID: (Human) 5290, (Mouse) 18706, (Rat) 170911

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Function(s)
protein serine/threonine kinase activity protein binding ATP binding kinase activity 1-phosphatidylinositol-3-kinase activity protein kinase activator activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor
Process(es)
angiogenesis liver development adaptive immune response glucose metabolic process protein phosphorylation inflammatory response phosphatidylinositol 3-kinase signaling phosphorylation platelet activation positive regulation of peptidyl-serine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process regulation of multicellular organism growth regulation of cellular respiration protein kinase B signaling negative regulation of neuron apoptotic process hypomethylation of CpG island innate immune response positive regulation of protein kinase activity phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling cell chemotaxis adipose tissue development cellular response to glucose stimulus energy homeostasis mitophagy in response to mitochondrial depolarization negative regulation of fibroblast apoptotic process regulation of genetic imprinting negative regulation of anoikis vasculature development phosphatidylinositol biosynthetic process epidermal growth factor receptor signaling pathway regulation of gene expression regulation of phosphatidylinositol 3-kinase signaling T cell costimulation activation of protein kinase activity insulin receptor signaling pathway via phosphatidylinositol 3-kinase Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway endothelial cell migration vascular endothelial growth factor receptor signaling pathway T cell receptor signaling pathway leukocyte migration cardiac muscle contraction
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