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Invitrogen
PIKFYVE Polyclonal Antibody
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Product Details
PA5-67981
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human PIKFYVE.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2691625
Product Specific Information
Predicted to react with Mouse samples.
Target Information
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; epididymis luminal protein 37; FYVE finger-containing phosphoinositide kinase; p235; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; PIKfyve; PIPkin-III; PtdIns(4)P-5-kinase; Serine-protein kinase PIKFYVE; type III PIP kinase; zinc finger, FYVE domain containing 29
Gene Aliases: 5230400C17Rik; CFD; FAB1; HEL37; KIAA0981; p235; PIKFYVE; PIP5K; PIP5K3; Pipk5k3; PipkIII; ZFYVE29
UniProt ID: (Human) Q9Y2I7, (Mouse) Q9Z1T6
Entrez Gene ID: (Human) 200576, (Mouse) 18711
1-phosphatidylinositol-3-phosphate 5-kinase activity
protein binding
ATP binding
zinc ion binding
1-phosphatidylinositol-4-phosphate 5-kinase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
nucleotide binding
kinase activity
phosphatidylinositol phosphate kinase activity
transferase activity
metal ion binding
phosphorylation
myelin assembly
protein localization to nucleus
intracellular signal transduction
retrograde transport, endosome to Golgi
phosphatidylinositol metabolic process
phosphatidylinositol phosphorylation
phosphatidylinositol biosynthetic process
receptor-mediated endocytosis
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol 5-phosphate metabolic process
regulation of autophagosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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