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Invitrogen
PIM1 Recombinant Rabbit Monoclonal Antibody (4C8D0)
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FIGURE: 1 / 6
PIM1 Antibody (MA5-35347) in IHC (P)
Immunohistochemistry analysis of PIM1 in paraffin-embedded human cervix. Samples were incubated with PIM1 monoclonal antibody (Product # MA5-35347) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-35347
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4C8D0
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PIM1 (P11309)
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849248
Product Specific Information
Immunogen sequence: MLLSKINSLA HLRAAPCNDL HATKLAPGKE KEPLESQYQV GPLLGSGGFG SVYSGIRVSD NLPVAIKHVE KDRISDWGEL PNGTRVPMEV VLLKKVSSGF
Target Information
The proto-oncogene PIM1 is upregulated in prostate cancer. PIM1, which belongs to the Serine/Threonine protein kinase family, is thought to play a role in signal transduction in blood cells. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer. It may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. PIM1 is expressed primarily in cells of the hematopoietic and germ line lineages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: non-specific serine/threonine protein kinase; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene; pim-1 oncogene (proviral integration site 1); proto-oncogene serine/threonine-protein kinase Pim-1; proviral integration site 1; Serine/threonine-protein kinase pim-1
Gene Aliases: PIM; Pim-1; PIM1
UniProt ID: (Human) P11309, (Rat) P26794, (Mouse) P06803
Entrez Gene ID: (Human) 5292, (Rat) 24649, (Mouse) 18712
protein phosphorylation
apoptotic process
cell cycle
multicellular organism development
cell proliferation
hyaluronan metabolic process
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
protein autophosphorylation
vitamin D receptor signaling pathway
regulation of mitotic cell cycle
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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