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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PINK1 Antibodies

          Proteintech

          PINK1 Polyclonal Antibody

          210 References
          View all (35) PINK1 antibodies

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          Cite PINK1 Polyclonal Antibody

          • Antibody Testing Data (9)
          PINK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          PINK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 9

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          PINK1 Antibody (23274-1-AP) in IHC (P)

          Immunohistochemical analysis of paraffin-embedded Mouse brain tissue slide using (Product # 23274-1-AP) PINK1 antibody at dilution of 1:2,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          PINK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PINK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PINK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PINK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PINK1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          PINK1 Antibody in Western Blot (WB)
          PINK1 Antibody in Western Blot (WB)
          PINK1 Antibody in Western Blot (WB)
          PINK1 Antibody in Western Blot (WB)

          Product Details

          23274-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          View 166 publications 166 publications

          Immunohistochemistry (IHC)

          -
          View 16 publications 16 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:500
          -

          Immunohistochemistry (PFA fixed) (IHC (PFA))

          1:50-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          View 25 publications 25 publications

          Immunoprecipitation (IP)

          -
          View 3 publications 3 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          PINK1 Fusion Protein Ag19825 (336-581 aa encoded by BC028215)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.2 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: PRLAAMMLL QLLEGVDHLV QQGIAHRDLK SDNILVELDP DGCPWLVIAD FGCCLADESI GLQLPFSSWY VDRGGNGCLM APEVSTARPG PRAVIDYSKA DAWAVGAIAY EIFGLVNPFY GQGKAHLESR SYQEAQLPAL PESVPPDVRQ LVRALLQREA SKRPSARVAA NVLHLSLWGE HILALKNLKL DKMVGWLLQQ SAATLLANRL TEKCCVETKM KMLFLANLEC ETLCQAALLL CSWRAAL (336-581 aa encoded by BC028215 )

          Target Information

          PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: BRPK; FLJ27236; PINK 1; PINK-1; protein kinase BRPK; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial

          View more View less

          Gene Aliases: 1190006F07Rik; AU042772; AW557854; BRPK; mFLJ00387; PARK6; PINK1

          View more View less

          UniProt ID: (Human) Q9BXM7, (Mouse) Q99MQ3

          View more View less

          Entrez Gene ID: (Human) 65018, (Rat) 298575, (Mouse) 68943

          View more View less

          Function(s)
          magnesium ion binding protease binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding calcium-dependent protein kinase activity kinase activity peptidase activator activity ubiquitin protein ligase binding protein kinase B binding C3HC4-type RING finger domain binding molecular_function nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding
          Process(es)
          mitophagy positive regulation of protein phosphorylation regulation of oxidative phosphorylation protein phosphorylation ubiquitin-dependent protein catabolic process response to stress response to oxidative stress mitochondrion organization regulation of hydrogen peroxide metabolic process negative regulation of gene expression regulation of mitochondrion organization positive regulation of peptidase activity macroautophagy positive regulation of macroautophagy negative regulation of macroautophagy phosphorylation protein ubiquitination peptidyl-serine phosphorylation respiratory electron transport chain regulation of protein ubiquitination positive regulation of protein ubiquitination activation of protein kinase B activity positive regulation of synaptic transmission, dopaminergic positive regulation of peptidyl-serine phosphorylation positive regulation of dopamine secretion cellular response to oxidative stress positive regulation of protein dephosphorylation intracellular signal transduction peptidyl-serine autophosphorylation TORC2 signaling positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly negative regulation of neuron apoptotic process positive regulation of translation negative regulation of JNK cascade protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of ubiquitin-protein transferase activity regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling regulation of proteasomal protein catabolic process cellular response to hypoxia establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission cellular response to toxic substance mitophagy in response to mitochondrial depolarization regulation of synaptic vesicle transport negative regulation of autophagosome assembly positive regulation of mitochondrial electron transport, NADH to ubiquinone regulation of mitophagy negative regulation of mitophagy negative regulation of oxidative stress-induced cell death negative regulation of oxidative stress-induced neuron death regulation of protein targeting to mitochondrion negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide positive regulation of cristae formation positive regulation of protein targeting to mitochondrion positive regulation of free ubiquitin chain polymerization regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process positive regulation of ATP biosynthetic process biological_process positive regulation of catecholamine secretion regulation of apoptotic process regulation of neuron apoptotic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway autophagy
          It has to be done as per old AB suggested Products section.
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