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PINX1 Polyclonal Antibody

PINX1 Antibody in Immunocytochemistry (ICC/IF)

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PINX1 Antibody (12368-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 12368-1-AP (PINX1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

PINX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

12368-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PINX1 Fusion Protein Ag3043 (1-328 aa encoded by BC015479)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSMLAERRR KQKWAVDPQN TAWSNDDSKF GQRMLEKMGW SKGKGLGAQE HGATDHIKVQ VKNNHLGLGA TINNEDNWIA HQDDFNQLLA ELNTCHGQET TDSSDKKEKK SFSLEEKSKI SKNRVHYMKF TKGKDLSSRS KTDLDCIFGK RQSKKTPEGD ASPSTPEENE TTTTSAFTIQ EYFAKRMAAL KNKPQVPVPG SDISETQVER KRGKKINKEA TGKDVESYLQ PKAKRHTEGK PERAEAQERV AKKKSAPAEE QLRGPCWDQS SKASAQDAGD HVQPPEGRDF TLKPKKRRGK KKLQKPVEIA EDATLEETLV KKKKKKDSK (1-328 aa encoded by BC015479 )

Target Information

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PINX1 promotes malignant transformation of thyroid cancer through the activation of the AKT/MAPK/β-catenin signaling pathway.

American journal of cancer research

Kang J,Park JH,Kong JS,Kim MJ,Lee SS,Park S,Myung JK

Wed Dec 08 00:00:00 UTC 2021

PINX1 promotes malignant transformation of thyroid cancer through the activation of the AKT/MAPK/β-catenin signaling pathway.

American journal of cancer research

Kang J,Park JH,Kong JS,Kim MJ,Lee SS,Park S,Myung JK

Wed Dec 08 00:00:00 UTC 2021

Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development.

Biochemical and biophysical research communications

Liu Y,Gong P,Zhou N,Zhang J,He C,Wang S,Peng H

Tue Jun 18 00:00:00 UTC 2019

The clinical significance of PINX1 expression in papillary thyroid carcinoma.

Human pathology

Kang J,Han K,Kim HJ,Park JH,Kong JS,Park S,Myung JK

Thu Nov 01 00:00:00 UTC 2018

The clinical significance of PINX1 expression in papillary thyroid carcinoma.

Human pathology

Kang J,Han K,Kim HJ,Park JH,Kong JS,Park S,Myung JK

Thu Nov 01 00:00:00 UTC 2018

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway.

Molecular cancer

Tian XP,Jin XH,Li M,Huang WJ,Xie D,Zhang JX

Tue Apr 04 00:00:00 UTC 2017

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway.

Molecular cancer

Tian XP,Jin XH,Li M,Huang WJ,Xie D,Zhang JX

Tue Apr 04 00:00:00 UTC 2017

PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis.

OncoTargets and therapy

Qian D,Cheng J,Ding X,Chen X,Chen X,Guan Y,Zhang B,Wang J,Er P,Qiu M,Zeng X,Guo Y,Wang H,Zhao L,Xie D,Yuan Z,Wang P,Pang Q

Thu Aug 18 00:00:00 UTC 2016

PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis.

OncoTargets and therapy

Qian D,Cheng J,Ding X,Chen X,Chen X,Guan Y,Zhang B,Wang J,Er P,Qiu M,Zeng X,Guo Y,Wang H,Zhao L,Xie D,Yuan Z,Wang P,Pang Q

Thu Aug 18 00:00:00 UTC 2016

PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis.

OncoTargets and therapy

Qian D,Cheng J,Ding X,Chen X,Chen X,Guan Y,Zhang B,Wang J,Er P,Qiu M,Zeng X,Guo Y,Wang H,Zhao L,Xie D,Yuan Z,Wang P,Pang Q

Thu Aug 18 00:00:00 UTC 2016

PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis.

OncoTargets and therapy

Qian D,Cheng J,Ding X,Chen X,Chen X,Guan Y,Zhang B,Wang J,Er P,Qiu M,Zeng X,Guo Y,Wang H,Zhao L,Xie D,Yuan Z,Wang P,Pang Q

Thu Aug 18 00:00:00 UTC 2016

The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.

Cancer letters

Tian XP,Qian D,He LR,Huang H,Mai SJ,Li CP,Huang XX,Cai MY,Liao YJ,Kung HF,Zeng YX,Xie D

Fri Oct 10 00:00:00 UTC 2014

The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.

Cancer letters

Tian XP,Qian D,He LR,Huang H,Mai SJ,Li CP,Huang XX,Cai MY,Liao YJ,Kung HF,Zeng YX,Xie D

Fri Oct 10 00:00:00 UTC 2014

The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.

Cancer letters

Tian XP,Qian D,He LR,Huang H,Mai SJ,Li CP,Huang XX,Cai MY,Liao YJ,Kung HF,Zeng YX,Xie D

Fri Oct 10 00:00:00 UTC 2014

The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.

Cancer letters

Tian XP,Qian D,He LR,Huang H,Mai SJ,Li CP,Huang XX,Cai MY,Liao YJ,Kung HF,Zeng YX,Xie D

Fri Oct 10 00:00:00 UTC 2014

PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway.

Molecular cancer

Liu JY,Qian D,He LR,Li YH,Liao YJ,Mai SJ,Tian XP,Liu YH,Zhang JX,Kung HF,Zeng YX,Zhou FJ,Xie D

Sat Nov 23 00:00:00 UTC 2013

PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway.

Molecular cancer

Liu JY,Qian D,He LR,Li YH,Liao YJ,Mai SJ,Tian XP,Liu YH,Zhang JX,Kung HF,Zeng YX,Zhou FJ,Xie D

Sat Nov 23 00:00:00 UTC 2013

PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway.

Molecular cancer

Liu JY,Qian D,He LR,Li YH,Liao YJ,Mai SJ,Tian XP,Liu YH,Zhang JX,Kung HF,Zeng YX,Zhou FJ,Xie D

Sat Nov 23 00:00:00 UTC 2013

PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway.

Molecular cancer

Liu JY,Qian D,He LR,Li YH,Liao YJ,Mai SJ,Tian XP,Liu YH,Zhang JX,Kung HF,Zeng YX,Zhou FJ,Xie D

Sat Nov 23 00:00:00 UTC 2013

Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation.

Oncogene

Zhang B,Qian D,Ma HH,Jin R,Yang PX,Cai MY,Liu YH,Liao YJ,Deng HX,Mai SJ,Zhang H,Zeng YX,Lin MC,Kung HF,Xie D,Huang JJ

Thu Jan 05 00:00:00 UTC 2012

Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation.

Oncogene

Zhang B,Qian D,Ma HH,Jin R,Yang PX,Cai MY,Liu YH,Liao YJ,Deng HX,Mai SJ,Zhang H,Zeng YX,Lin MC,Kung HF,Xie D,Huang JJ

Thu Jan 05 00:00:00 UTC 2012

Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma.

Cancer science

Cai MY,Zhang B,He WP,Yang GF,Rao HL,Rao ZY,Wu QL,Guan XY,Kung HF,Zeng YX,Xie D

Tue Jun 01 00:00:00 UTC 2010

Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma.

Cancer science

Cai MY,Zhang B,He WP,Yang GF,Rao HL,Rao ZY,Wu QL,Guan XY,Kung HF,Zeng YX,Xie D

Tue Jun 01 00:00:00 UTC 2010

Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma.

Cancer science

Cai MY,Zhang B,He WP,Yang GF,Rao HL,Rao ZY,Wu QL,Guan XY,Kung HF,Zeng YX,Xie D

Tue Jun 01 00:00:00 UTC 2010

Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma.

Cancer science

Cai MY,Zhang B,He WP,Yang GF,Rao HL,Rao ZY,Wu QL,Guan XY,Kung HF,Zeng YX,Xie D

Tue Jun 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: 67-11-3 protein; FLJ20565; hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTS1; MGC8850; PIN2 interacting protein 1; pin2-interact; PIN2-interacting protein 1; PIN2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PIN2/TRF1-interacting protein; pinx1 {ECO:0000312|EMBL:ABO28828.1}; Protein 67-11-3; TRF1-interacting protein 1

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Gene Aliases: 2210403I16Rik; 2610028A01Rik; 67-11-3; AU024023; LPTL; LPTS; LPTS1; PINX1; RGD1566025

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UniProt ID: (Human) Q96BK5, (Rat) A4L691, (Mouse) Q9CZX5

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Entrez Gene ID: (Human) 54984, (Rat) 305963, (Mouse) 72400

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Function(s)

protein binding telomerase inhibitor activity telomerase RNA binding nucleic acid binding

Process(es)

telomere maintenance via telomerase mitotic metaphase plate congression negative regulation of cell proliferation negative regulation of protein ubiquitination regulation of protein stability negative regulation of telomere maintenance via telomerase regulation of telomerase activity negative regulation of telomerase activity protein localization to chromosome, telomeric region protein localization to nucleolus negative regulation of telomere maintenance via telomere lengthening positive regulation of telomeric DNA binding positive regulation of protein localization to nucleolus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PINX1 Polyclonal Antibody

PINX1 Antibody (12368-1-AP) in ICC/IF

Product Details

12368-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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