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Abnova
PIP5K3 Polyclonal Antibody, MaxPab™
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Product Details
H00200576-B02P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PIP5K3 (NP_689884.1, 1 a.a. approximately 451 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MATDDKTSPT LDSANDLPRS PTSPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERA EGGQGEQQPL SGSWTSPQLP SRTQSVRSPT PYKKQLNEEL QRRSSALGDL RACTYCRKIA LSYAHSTDSN SIGEDLNALS DSACSVSVLD PSEPRTPVGS RKASRNIFLE DDLAWQSLIH PDSSNTPLST RLVSVQEDAG KSPARNRSAS ITNLSLDRSG SPMVPSYETS VSPQANRTYV RTETTEDERK ILLDSVQLKD LWKKICHHSS GMEFQDHRYW LRTHPNCIVG KELVNWLIRN GHIATRAQAI AIGQAMVDGR WLDCVSHHDQ LFRDEYALYR PLQSTEFSET PSPDSDSVNS VEGHSEPSWF KDIKFDDSDT EQIAEEGDDN LANSASPSKR TSVSSFQSTV DSDSAASISL NVELDNVNFH IKKPSKYPHV PPHPADQKGR R
Target Information
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; epididymis luminal protein 37; FYVE finger-containing phosphoinositide kinase; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; PIKfyve; PIPkin-III; Serine-protein kinase PIKFYVE; type III PIP kinase; zinc finger, FYVE domain containing 29
Gene Aliases: CFD; FAB1; HEL37; KIAA0981; PIKFYVE; PIP5K; PIP5K3; ZFYVE29
UniProt ID: (Human) Q9Y2I7
Entrez Gene ID: (Human) 200576
phosphatidylinositol biosynthetic process
receptor-mediated endocytosis
myelin assembly
protein localization to nucleus
intracellular signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
retrograde transport, endosome to Golgi
phosphatidylinositol phosphorylation
phosphatidylinositol 5-phosphate metabolic process
regulation of autophagosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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