Proteintech

PITX1 Polyclonal Antibody

PITX1 Antibody in Immunocytochemistry (ICC/IF)

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PITX1 Antibody (10873-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using PITX1 antibody 10873-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

PITX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PITX1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10873-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PITX1 Fusion Protein Ag1303 (1-314 aa encoded by BC009412)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDAFKGGMS LERLPEGLRP PPPPPHDMGP AFHLARPADP REPLENSASE SSDTELPEKE RGGEPKGPED SGAGGTGCGG ADDPAKKKKQ RRQRTHFTSQ QLQELEATFQ RNRYPDMSMR EEIAVWTNLT EPRVRVWFKN RRAKWRKRER NQQLDLCKGG YVPQFSGLVQ PYEDVYAAGY SYNNWAAKSL APAPLSTKSF TFFNSMSPLS SQSMFSAPSS ISSMTMPSSM GPGAVPGMPN SGLNNINNLT GSSLNSAMSP GACPYGTPAS PYSVYRDTCN SSLASLRLKS KQHSSFGYGG LQGPASGLNA CQYNS (1-314 aa encoded by BC009412)

Target Information

PITX1 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Nature

Burda JE,O'Shea TM,Ao Y,Suresh KB,Wang S,Bernstein AM,Chandra A,Deverasetty S,Kawaguchi R,Kim JH,McCallum S,Rogers A,Wahane S,Sofroniew MV

Wed Jun 01 00:00:00 UTC 2022

G3BP1 binds to guanine quadruplexes in mRNAs to modulate their stabilities.

Nucleic acids research

He X,Yuan J,Wang Y

Mon Nov 08 00:00:00 UTC 2021

Mandibular-pelvic-patellar syndrome is a novel PITX1-related disorder due to alteration of PITX1 transactivation ability.

Human mutation

Morel G,Duhamel C,Boussion S,Frénois F,Lesca G,Chatron N,Labalme A,Sanlaville D,Edery P,Thevenon J,Faivre L,Fassier A,Prodhomme O,Escande F,Manouvrier S,Petit F,Geneviève D,Rossi M

Tue Sep 01 00:00:00 UTC 2020

Mandibular-pelvic-patellar syndrome is a novel PITX1-related disorder due to alteration of PITX1 transactivation ability.

Human mutation

Morel G,Duhamel C,Boussion S,Frénois F,Lesca G,Chatron N,Labalme A,Sanlaville D,Edery P,Thevenon J,Faivre L,Fassier A,Prodhomme O,Escande F,Manouvrier S,Petit F,Geneviève D,Rossi M

Tue Sep 01 00:00:00 UTC 2020

Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.

The international journal of biochemistry & cell biology

Jin Y,Qin X

Thu Oct 01 00:00:00 UTC 2020

Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.

The international journal of biochemistry & cell biology

Jin Y,Qin X

Thu Oct 01 00:00:00 UTC 2020

Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.

Endocrinology

Kameda H,Yamamoto M,Tone Y,Tone M,Melmed S

Fri Feb 01 00:00:00 UTC 2019

All-trans-retinoid acid (ATRA) may have inhibited chondrogenesis of primary hind limb bud mesenchymal cells by downregulating Pitx1 expression.

Toxicology letters

Wang YG,Li XD,Liu ZY,Zhang TG,Chen B,Hou GQ,Hong Q,Xie P,Du SX

Mon Jan 13 00:00:00 UTC 2014

All-trans-retinoid acid (ATRA) may have inhibited chondrogenesis of primary hind limb bud mesenchymal cells by downregulating Pitx1 expression.

Toxicology letters

Wang YG,Li XD,Liu ZY,Zhang TG,Chen B,Hou GQ,Hong Q,Xie P,Du SX

Mon Jan 13 00:00:00 UTC 2014

All-trans-retinoid acid (ATRA) may have inhibited chondrogenesis of primary hind limb bud mesenchymal cells by downregulating Pitx1 expression.

Toxicology letters

Wang YG,Li XD,Liu ZY,Zhang TG,Chen B,Hou GQ,Hong Q,Xie P,Du SX

Mon Jan 13 00:00:00 UTC 2014

All-trans-retinoid acid (ATRA) may have inhibited chondrogenesis of primary hind limb bud mesenchymal cells by downregulating Pitx1 expression.

Toxicology letters

Wang YG,Li XD,Liu ZY,Zhang TG,Chen B,Hou GQ,Hong Q,Xie P,Du SX

Mon Jan 13 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: hindlimb expressed homeobox protein backfoot; Hindlimb-expressed homeobox protein backfoot; Homeobox protein P-OTX; Homeobox protein PITX1; OTX; paired-like homeodomain 1; Paired-like homeodomain transcription factor 1; pituitary homeo box 1; Pituitary homeobox 1; Pituitary OTX-related factor

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Gene Aliases: BFT; CCF; LBNBG; P-OTX; PITX1; POTX; PTX1

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UniProt ID: (Human) P78337, (Mouse) P70314

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Entrez Gene ID: (Human) 5307, (Mouse) 18740

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding protein binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding

Process(es)

skeletal system development transcription from RNA polymerase II promoter anatomical structure morphogenesis branchiomeric skeletal muscle development pituitary gland development embryonic hindlimb morphogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter myoblast fate commitment cartilage development transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development hindlimb morphogenesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PITX1 Polyclonal Antibody

PITX1 Antibody (10873-1-AP) in ICC/IF

Product Details

10873-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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