OriGene

PITX2 Monoclonal Antibody (OTI1H10), TrueMAB™

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CF809670

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI1H10

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-200 of human PITX2 produced in E.coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: all1-responsive gene 1; ALL1-responsive protein ARP1; Bicoid-related homeobox protein 1; BRX1 homeoprotein; Homeobox protein PITX2; homeodomain transcription factor 2; Orthodenticle-like homeobox 2; paired-like homeodomain 2; Paired-like homeodomain transcription factor 2; paired-like homeodomain transcription factor Munc 30; Pituitary homeobox 2; RIEG bicoid-related homeobox transcription factor; rieg bicoid-related homeobox transcription factor 1; rPtx2; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S α 1 glycoprotein; S α1glycoprotein; Solurshin

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Gene Aliases: 9430085M16Rik; ARP1; Brx1; Brx1b; IDG2; IGDS; IGDS2; IHG2; IRID2; Munc30; Otlx2; Pitx-2; PITX2; Pitx2c; PTX2; RGS; RIEG; RIEG1; RS

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UniProt ID: (Human) Q99697, (Rat) Q9R0W1, (Mouse) P97474

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Entrez Gene ID: (Human) 5308, (Rat) 54284, (Mouse) 18741

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding chromatin DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional repressor activity, RNA polymerase II transcription factor binding DNA binding chromatin binding identical protein binding protein homodimerization activity sequence-specific DNA binding phosphoprotein binding
Process(es)
patterning of blood vessels vasculogenesis in utero embryonic development neuron migration extraocular skeletal muscle development atrioventricular valve development cardiac neural crest cell migration involved in outflow tract morphogenesis pulmonary myocardium development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter determination of left/right symmetry myoblast fusion male gonad development female gonad development response to hormone Wnt signaling pathway subthalamic nucleus development hypothalamus cell migration regulation of cell migration embryonic camera-type eye development response to vitamin A embryonic hindlimb morphogenesis hair cell differentiation vascular smooth muscle cell differentiation deltoid tuberosity development odontogenesis of dentin-containing tooth odontogenesis camera-type eye development positive regulation of DNA binding positive regulation of transcription from RNA polymerase II promoter spleen development embryonic digestive tract morphogenesis atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle cell development somatotropin secreting cell differentiation prolactin secreting cell differentiation ventricular septum morphogenesis left lung morphogenesis pulmonary vein morphogenesis superior vena cava morphogenesis endodermal digestive tract morphogenesis iris morphogenesis cell proliferation involved in outflow tract morphogenesis left/right axis specification positive regulation of myoblast proliferation negative regulation of transcription from RNA polymerase II promoter brain development heart development skeletal muscle tissue development anatomical structure morphogenesis organ morphogenesis pituitary gland development neuron differentiation lung development regulation of cell proliferation positive regulation of transcription, DNA-templated cardiac muscle tissue development cardiac muscle cell differentiation digestive system development multicellular organism development
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