Proteintech

PKA C-beta Polyclonal Antibody

PKA C-beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PKA C-beta Antibody (55382-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney slide using 55382-1-AP ( PKA C-beta-specifc antibody at dilution of 1:50.

PKA C-beta Antibody in Western Blot (WB)

Product Image Gallery

Product Details

55382-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to PRKACB.

Target Information

The catalytic subunit C-beta of PKA (PRKACB) is a member of the Ser/Thr protein kinase family (the PKA catalytic subunit consist of three gene products: C-alpha, C-beta, and C-gamma) and has been assigned to human chromosome region 1p36.1. PRKACB is derived from a gene distinct from C-alpha and shows tissue-specific expression. At the amino acid level C-alpha and C-beta showed 93% homology. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

McCune-Albright syndrome associated with pituitary adenoma: a clinicopathological study of ten cases and literature review.

British journal of neurosurgery

Li Z,Liu R,Liu P

Thu Aug 01 00:00:00 UTC 2024

The delta subunit of the GABA_A receptor is necessary for the GPT2-promoted breast cancer metastasis.

Theranostics

Li N,Xu X,Liu D,Gao J,Gao Y,Wu X,Sheng H,Li Q,Mi J

Tue Mar 21 00:00:00 UTC 2023

Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells.

Journal of the Endocrine Society

Yan MQ,Wang Y,Wang Z,Liu XH,Yang YM,Duan XY,Sun H,Liu XM

Mon Mar 06 00:00:00 UTC 2023

Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms.

Environment international

Liu C,Liu Z,Fang Y,Liao Z,Zhang Z,Yuan X,Yu T,Yang Y,Xiong M,Zhang X,Zhang G,Meng L,Zhang Z

Sun Jan 01 00:00:00 UTC 2023

Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.

Journal of immunology research

Hong Q,Zhang Y,Lin W,Wang W,Yuan Y,Lin J,Xie Z,Li X,Meng Y

Tue Aug 30 00:00:00 UTC 2022

Journal of immunology research

Hong Q,Zhang Y,Lin W,Wang W,Yuan Y,Lin J,Xie Z,Li X,Meng Y

Tue Aug 30 00:00:00 UTC 2022

Different lipid metabolic profiles and their associated genes in sessile serrated adenoma or polyps compared to hyperplastic polyps.

American journal of cancer research

Tang C,Li J,Yang Z,Chen Y,Zeng C

Sat Jul 16 00:00:00 UTC 2022

H3F3A K27M Mutation Promotes the Infiltrative Growth of High-Grade Glioma in Adults by Activating β-Catenin/USP1 Signaling.

Cancers

Sun Z,Zhu Y,Feng X,Liu X,Zhou K,Wang Q,Zhang H,Shi H

Mon Oct 03 00:00:00 UTC 2022

GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.

Oncogenesis

Zhao C,Yu H,Fan X,Niu W,Fan J,Sun S,Gong M,Zhao B,Fang Z,Chen X

Mon May 23 00:00:00 UTC 2022

Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats.

Annals of translational medicine

Nie Q,Dong W,Shen B,Yang G,Yu H,Zhang R,Peng Y,Yu Y,Hong S,Li L

Thu Sep 01 00:00:00 UTC 2022

Per1/Per2 Disruption Reduces Testosterone Synthesis and Impairs Fertility in Elderly Male Mice.

International journal of molecular sciences

Liu Q,Wang H,Wang H,Li N,He R,Liu Z

Sat Jul 02 00:00:00 UTC 2022

Quercetin, Engelitin and Caffeic Acid of Smilax china L. Polyphenols, Stimulate 3T3-L1 Adipocytes to Brown-like Adipocytes Via β3-AR/AMPK Signaling Pathway.

Plant foods for human nutrition (Dordrecht, Netherlands)

Kong L,Zhang W,Liu S,Zhong Z,Zheng G

Thu Dec 01 00:00:00 UTC 2022

Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT_1A receptor: Insights from transcriptomics.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Qiao YL,Zhou JJ,Liang JH,Deng XP,Zhang ZJ,Huang HL,Li S,Dai SF,Liu CQ,Luan ZL,Yu ZL,Sun CP,Ma XC

Fri Jan 01 00:00:00 UTC 2021

Total barley maiya alkaloids inhibit prolactin secretion by acting on dopamine D2 receptor and protein kinase A targets.

Journal of ethnopharmacology

Gong X,Tao J,Wang Y,Wu J,An J,Meng J,Wang X,Chen Y,Zou J

Sat Jun 12 00:00:00 UTC 2021

Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo.

Pharmacological research

Liang C,Li Y,Bai M,Huang Y,Yang H,Liu L,Wang S,Yu C,Song Z,Bao Y,Yi J,Sun L,Li Y

Sun Mar 01 00:00:00 UTC 2020

Label-Free Quantitative Phosphoproteomics Reveals Regulation of Vasodilator-Stimulated Phosphoprotein upon Stathmin-1 Silencing in a Pair of Isogenic Colorectal Cancer Cell Lines.

Proteomics

Tan HT,Chung MCM

Sun Apr 01 00:00:00 UTC 2018

Label-Free Quantitative Phosphoproteomics Reveals Regulation of Vasodilator-Stimulated Phosphoprotein upon Stathmin-1 Silencing in a Pair of Isogenic Colorectal Cancer Cell Lines.

Proteomics

Tan HT,Chung MCM

Sun Apr 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; protein kinase A catalytic subunit beta; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, beta

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Gene Aliases: PKA C-beta; PKACB; PRKACB

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UniProt ID: (Human) P22694, (Rat) P68182, (Mouse) P68181

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Entrez Gene ID: (Human) 5567, (Rat) 293508, (Mouse) 18749

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Function(s)

magnesium ion binding protein serine/threonine kinase activity cAMP-dependent protein kinase activity protein binding ATP binding kinase activity ubiquitin protein ligase binding protein kinase A regulatory subunit binding nucleotide binding protein kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

neural tube closure stimulatory C-type lectin receptor signaling pathway renal water homeostasis protein phosphorylation signal transduction adenylate cyclase-modulating G-protein coupled receptor signaling pathway blood coagulation activation of protein kinase A activity lipoprotein metabolic process negative regulation of meiotic cell cycle regulation of protein processing cellular response to glucagon stimulus response to clozapine negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PKA C-beta Polyclonal Antibody

PKA C-beta Antibody (55382-1-AP) in IHC (P)

Product Details

55382-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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